Results 191 to 200 of about 53,594 (285)
Ultrasound‐Actuated Gene Editing in Human Kidney Organoids
Advanced Science, EarlyView.Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina +6 morewiley +1 more sourceSelecting stopping muons with KM3NeT/ORCA
The KM3NeT collaboration operates two water Cherenkov neutrino telescopes in the Mediterranean sea, ORCA and ARCA. The flux of atmospheric muons produced in cosmic ray air showers forms a background to the main objectives of KM3NeT/ORCA and KM3NeT/ARCA ...Guidi C., Chen A., James C. W., Sgura I., Orlando A., Samtleben D. F. E., Moussa A., Wilms J., Filippini F., Labalme M., Lastoria C., Androutsou E., Saina A., Van Elewyck V., Manfreda A., Salesa Greus F., El Bojaddaini I., Thiersen H., Morales-Gallegos L., Hernandez-Rey J. J., Sennan N., Garcia Soto A., Eff M., Gal T., Bariego-Quintana A., Levi G., Oliviero V., Nauta L., Margiotta A., Ardid S., Biagi S., Schumann J., Dallier R., Sinopoulou A., Cecchini V., Boettcher M., Majumdar J., Oukacha E., Coelho J. A. B., Huang F., Benhassi M., Gabriel J., Buis E., Martinez-Mora J. A., Basegmez du Pree S., Branzas H., Carenini F., Mamedov F., Pastor Gomez E. J., Lessing N., Robinson J., Martin L., Vannoye G., Khan Chowdhury N. R., Castaldi P., Stekl I., Aiello S., Dornic D., Calvo D., de Jong M., Micciche S., Migneco E., Parisi V., Bouwhuis M., Benoit D. M., Leonora E., Musumeci M., Smirnov M. V., Zuniga J., Romanov A., Coniglione R., Creusot A., Quiroz C., Mastroianni S., Hekalo A., Valsecchi V., Fearraigh B. O., Aublin J., Busto J., Carretero V., Zornoza J. D., Idrissi Ibnsalih W., Bailly-Salins L., Dorr M., Garcia Mendez J., Ameli F., Geisselbrecht N., Enzenhofer A., Heijboer A., Capone A., Bozza C., Randriatoamanana R., Distefano C., Rea I. C., Lazo A., Gagliardini S., Buompane R., Gracia R., De Benedittis A., Drouhin D., Verilhac C., Santonastaso C., Baret B., Ghaddari H., Poire C., Quemener G., van Haren H., Sanchez Losa A., Paun A. M., Sanguineti M., Coyle P., Cocimano R., Gibson B. K., Zarpapis G., Mastrodicasa M., Albert A., de Jong P., Kopper C., Bonanno D., Schnabel J., Drakopoulou E., Vivolo D., Marconi M., Kulikovskiy V., Celli S., Di Mauro L. S., Marinelli A., Mitsou M. L., Simonelli A., Kalekin O., Jung B. J., Zywucka N., Berbee E., Seneca J., Bendahman M., Zito D., Marzaioli F., Tayalati Y., Riccobene G., Kouchner A., Benfenati F., Zavatarelli S., Andre M., Pestes R., El Hedri S., Tzamariudaki E., Nicolau C. A., Campion S., Illuminati G., Pulvirenti S., Gialanella L., Lehaut G., Schutte H. M., Coleiro A., Sapienza P., Diego-Tortosa D., Graf K., Eberl T., Kistauri G., Ardid M., Randazzo N., Goos I., Kalaczynski P., Mollo C. M., Nayerhoda A., Pavalas G. E., Rahaman U., Shitov Y., Yepes-Ramirez H., Giorgio E., Palacios Gonzalez J., Cerisy L., Darras Y., Reck S., Dvornicky R., Goupilliere D., Ambrosone A., Bertin V., Gozzini S. R., Piattelli P., Franciotti D., Setter B., Filipovic M. D., Cruz A., Del Burgo R., Spurio M., Zegarelli A., Tsourapis V., Bretaudeau F., Bozza R. M., Cuttone G., Eddymaoui A., Bardacova Z., Gutierrez M., Razzaque S., Taiuti M., Vazquez de Sola F., Pestel V., Chabab M., Pena Martinez S., van Eijk D., Circella M., Ferrara G., Le Stum S., Pradier T., Simkovic F., Navas S., Bouta M., Diaz A. F., Eckerova E., Stavropoulos D., Nkosi B., Sanfilippo S., Paesani D., Domi A., Hennig L., Muller R., Bruno R., Spisso B., Atmani H., Migliozzi P., Larosa G., Morley-Wong C., Decoene V., Lahmann R., Chadolias M., Papalashvili G., Katz U. F., Vacheret A., Veutro A., Anguita M., Boumaaza J., Di Cerbo U. M., Becherini Y., Fusco L. A., Cartraud T., Kvatadze R., Guillon B., Tosta e Melo I., Brunner J., Bruijn R., Real D., Markou C., Trocme B., Perronnel J., Musone M. R., Alves Garre S., Vasileiadis G., Chiarusi T., de Wolf E., Manczak J., Mozun Mateo I., Viola S., Popa V., Khatun A., Lindsey Clark M., Longhitano F., Cherubini S., Miele G., Caiffi B., Malerba L., Di Palma I., Diaz C., De Martino B., Aly Z., Shanidze R., van Eeden T., Perrin-Terrin M., Gatius Oliver C., Santonocito D., Donzaud C., Tedjditi H., Aphecetche L. +272 morecore Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease
Advanced Science, EarlyView.The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich +13 morewiley +1 more sourceHaplotype‐Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine
Advanced Science, EarlyView.This study presents a haplotype‐resolved 3D genomic landscape of grapevine, revealing that structural variations (SVs) are closely associated with phased topologically associating domain (TAD) boundary transitions. These rearrangements coordinate with allele‐specific DNA methylation (ASM) and allele‐biased gene expression (ASE) to shape key agronomic ...Yanling Peng, Lianzhu Zhou, Xinyue Fang, Ruoyan Zhao, Qi Xu, Mengrui Du, Ting Hou, Guizhou Huang, Yingchun Zhang, Sheng Yan, Ruo Yang, Zhongxin Jin, Yang Dong, Yanshuai Xu, Hua Xiao, Xiaodong Xu, Yi Liao, Xiping Wang, Yongfeng Zhou +18 morewiley +1 more sourceTargeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain
Advanced Science, EarlyView.In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng +27 morewiley +1 more source
