The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
A systematic survey of randomised trials that stopped early for reasons of futility
BMC Medical Research Methodology, 2020 Background Randomised trial protocols may incorporate interim analyses, with the potential to stop the study for futility if early data show insufficient promise of a treatment benefit. Previously, we have shown that this approach will theoretically lead
S. D. Walter +7 more
doaj +1 more source
Machine learning methods for fission product identification from Bragg curves
AIP Advances, 2023 A fission time projection chamber (fission-TPC) was developed to provide precise neutron-induced fission measurements for several major actinides. As fission fragments lose energy in one of the gas volumes of the fission-TPC, energy loss information is ...
S. M. Lyons +6 more
doaj +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Further Operations (Complement, Intersection, Union) for IndetermSoft Set, IndetermHyperSoft Set, and TreeSoft Set and their Applications [PDF]
In this paper, efforts are intensified as much as possible to explicitly and clearly give the definitions as regards the operations involving the complement, intersection as well as the union for IndetermSoft Set, IndetermHyperSoft Set, and Tree Soft Set
Adesina, Adebisi Sunday
core +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
An Elementary Proof that the First Hitting Time of an Open Set by a Jump Process is a Stopping Time [PDF]
, 2012 We give a short and elementary proof that the first hitting time of an open set by the jump process of a cadlag adapted process is a stopping time.
Alexander Sokol
semanticscholar +1 more source
Non Stopping Times and Stopping Theorems [PDF]
, 2007 Given a random time, we give some characterizations of the set of martingales for which the stopping theorems still hold. We also investigate how the stopping theorems are modified when we consider arbitrary random times.
Nikeghbali, A, Nikeghbali, Ashkan
core +1 more source
Symbolic Early Stopping in Neural Sequence Models via Mapper-Induced Symbolic Dynamics
TechnologiesEarly stopping is a standard form of implicit regularization in neural sequence models, but criteria based solely on validation loss can become unstable or weakly informative in noisy, non-stationary, or weakly separated regimes.
Ivan Tomilov +3 more
doaj +1 more source
Legal regulation of the international road transport of passengers [PDF]
Zbornik Radova: Pravni Fakultet u Novom Sadu, 2017 Since March 2013 bus and coach passengers have a minimum set of rights when travelling in the European Union. Regulation 181/2011 concerning the rights of passengers in bus and coach transport applies to passengers traveling with regular services that ...
Đurđev Dušanka J.
doaj +1 more source