Results 51 to 60 of about 5,119,744 (306)

Optimal stopping with signatures

, 2023
We propose a new method for solving optimal stopping problems (such as American option pricing in finance) under minimal assumptions on the underlying stochastic process. We consider classic and randomized stopping times represented by linear functionals
Bayer, Christian, Schoenmakers, John G. M., Riedel, Sebastian, Hager, Paul   +3 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Phase- and GVF-Based Level Set Segmentation of Ultrasonic Breast Tumors

Journal of Applied Mathematics, 2012
Automatically extracting breast tumor boundaries in ultrasound images is a difficult task due to the speckle noise, the low image contrast, the variance in shapes, and the local changes of image intensity.
Liang Gao, Xiaoyun Liu, Wufan Chen
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Symbolic Early Stopping in Neural Sequence Models via Mapper-Induced Symbolic Dynamics

Technologies
Early stopping is a standard form of implicit regularization in neural sequence models, but criteria based solely on validation loss can become unstable or weakly informative in noisy, non-stationary, or weakly separated regimes.
Ivan Tomilov, Rodion Zamotaev, Natalia Gusarova, Aleksandra Vatian   +3 more
doaj   +1 more source

Resonant charging and stopping power of slow channelling atoms in a crystalline metal [PDF]

, 2012
18.09.12 KB. Published PDF, ok to add to spiral, as in OA journal.
Mason, DR, Foulkes, W. M C, Race, C., Race, CP, Mason, D. R., Sutton, A. P., Foulkes, W., Horsfield, A. P., Foo, M. H. F., Foo, M. H F, Foulkes, W. M. C., Foo, M., Foulkes, WMC, Horsfield, AP, Foo, MHF, Sutton, AP, Race, C. P., Mason, D., Sutton, A., Horsfield, A.   +19 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Integrated Optimization of Train Stop Planning and Scheduling on Metro Lines With Express/Local Mode

IEEE Access, 2019
Train stopping patterns and schedules play critical roles in the service design of metro lines with express/local mode. Previous studies on express/local mode generally handle the design of train stopping patterns and schedules independently, which ...
Zhujun Li, Baohua Mao, Yun Bai, Yao Chen
doaj   +1 more source

Ion stopping in dense plasma target for high energy density physics [PDF]

, 2010
The basic physics of nonrelativistic and electromagnetic ion stopping in hot and ionized plasma targets is thoroughly updated. Corresponding projectile-target interactions involve enhanced projectile ionization and coupling with target free electrons ...
Hasegawa, Jun, Sharkov, Boris Y., Deutsch, Claude, Chabot, Marin, Golubev, Alexey A., Ogawa, Masao, Bimbot, René, Jacoby, Joachim, Couillaud, Christophe, Mintsev, Victor, Della-Negra, Serge, Hoffmann, Dieter H. H., Wahl, H., Weyrich, Karin, Gardes, Daniel, Fleurier, Claude, Fertman, Alexander, Maynard, Gilles, Rivet, Marie-France, Tahir, Naeem Ahmad, Rosmej, Olga N., Fortov, Vladimir E., Oguri, Yoshiyuki   +22 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source