Results 161 to 170 of about 6,354,906 (437)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Monetary Policy in a Small Economy after Tsunami: A New Consensus on the Horizon? [PDF]

open access: yes
The last financial crisis significantly changed views concerning the relationship between monetary policy, asset prices and financial stability.
Jan Frait   +2 more
core  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Real Implications of Bursting Asset Price Bubbles in Economies with Bank Credit [PDF]

open access: yes
We study the consequences of equity mispricing (a bubble) and the correction thereof (the bubble bursting) for real activity in a production economy.
Alexis Derviz
core  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Optimal Sizing of Fuel Cell and Battery in a Direct-Hybrid for Electric Aircraft

open access: yesAerospace
The climate impact of aviation can be reduced using powertrains based on hydrogen fuel cells and batteries. Combining both technologies in a direct-hybrid without a DC/DC converter is a promising approach for light-weight systems.
Tobias Graf   +4 more
doaj   +1 more source

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