Results 31 to 40 of about 61,618 (264)

Improving Order-picking Operations with Precedence Constraints through Efficient Storage Location Assignment

U.Porto Journal of Engineering, 2021
This paper is inspired by a manual picking retail company where shape and weight constraints affect the order-picking process. We proposed an alternative clustering similarity index that considers the similarity, the weight and the shape of products ...
Maria Trindade, Paulo Sousa, Maria Moreira   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

An efficient correlation-based storage location assignment heuristic for multi-block multi-aisle warehouses [PDF]

International Journal of Industrial Engineering and Management
The most labor-intensive and time-consuming part of warehouse operations is order picking. This paper proposes a correlation-based storage location assignment (CBSLA) approach to minimize the travel distance of the picker in a picker-to-parts warehouse ...
Md. Saiful Islam, Md. Kutub Uddin
doaj   +1 more source

System Condition for Power Balancing between Fluctuating and Controllable Devices and Optimizing Storage Sizes

Energies, 2022
With the rapid development of distributed generators (DGs) and increasing power penetration level of renewable energy sources (RESs), it is a critical issue for any power system to operate safely and continuously in the presence of uncertainty and ...
Saher Javaid, Mineo Kaneko, Yasuo Tan
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A Network-Based Model for Optimization of Container Location Assignment at Inland Terminals

Applied Sciences, 2022
The development of inland terminals helps seaports mitigate inevitable storage capacity problems, extending their gravitational field and strengthening their competitive advantage.
Tomislav Rožić, Božidar Ivanković, Ivona Bajor, Martin Starčević   +3 more
doaj   +1 more source

Duration-of-Stay Storage Assignment under Uncertainty

, 2019
Optimizing storage assignment is a central problem in warehousing. Past literature has shown the superiority of the Duration-of-Stay (DoS) method in assigning pallets, but the methodology requires perfect prior knowledge of DoS for each pallet, which is unknown and uncertain under realistic conditions.
Michael Lingzhi Li, Elliott Wolf, Daniel Wintz   +2 more
openaire   +3 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Assignment of storage values to sequential read-write memories [PDF]

Proceedings EURO-DAC '96. European Design Automation Conference with EURO-VHDL '96 and Exhibition, 2002
Sequential read-write memories (SRWMs) are RAMs without an address decoder. A shift register is used instead to point at subsequent memory locations. SRWMs consume less power than RAMs of the same size. Algorithms are presented to check whether a set of storage values fits in a single SRWM and to automatically map storage values in as few SRWMs as ...
Sabih H. Gerez, Erwin G. Woutersen
openaire   +1 more source