Results 41 to 50 of about 261,458 (262)
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Frontiers in Forests and Global ChangeTropical agroforestry systems can mitigate climate change through carbon storage while supporting biodiversity and improving livelihoods. This study evaluates the potential of coffee agroforestry systems in the Gayo Highlands, Indonesia, to achieve ...
Ashabul Anhar +10 more
doaj +1 more source
Location and Capacity Optimization of Distributed Energy Storage System in Peak-Shaving
Energies, 2020 The peak-valley characteristic of electrical load brings high cost in power supply coming from the adjustment of generation to maintain the balance between production and demand.
Ruiyang Jin +4 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Advances in Horticultural Science, 2020 This study was aimed to investigate the quality at harvest and during storage of organically and conventionally grown ‘Italia’ grapes, collected from 2 different locations in Southern Italy.
Maria Luisa Amodio, Giancarlo Colelli
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Optimal location and sizing of storage units in a drainage system [PDF]
Environmental Modelling & Software, 2016 Adapting urban stormwater drainage systems is essential to handling increased urbanization and climate change. Within an urban area, storage units are an efficient solution to reduce peak runoff, but their implementation involves complex decisions. This paper presents a novel optimization model for defining, in existing sewer drainage systems, the ...
Maria C. Cunha +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source