Results 31 to 40 of about 22,090 (260)

Integrated Optimization of Mixed Cargo Packing and Cargo Location Assignment in Automated Storage and Retrieval Systems

Discrete Dynamics in Nature and Society, 2019
To improve the delivery efficiency of automated storage and retrieval system, the problem of the integrated optimization of mixed cargo packing and cargo location assignment is addressed.
Bin Lei, Zhaoyuan Jiang, Haibo Mu
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Storage Location Assignment Heuristics Based on Slot Selection and Frequent Itemset Grouping for Large Distribution Centers

IEEE Access, 2020
This paper considers heuristic approaches that can be used to assign stock keeping units (SKU) to individual slots in distribution center. Firstly, we propose two novel strategies, slot selection and frequent itemset grouping.
Junwoo Kim, Francis Mendez, Jesus Jimenez   +2 more
doaj   +1 more source

AHP algorithm used to select suitable abandoned underground mines for energy storage infrastructure – iCAES technology. A specific case study for León (Spain)

Heliyon, 2023
In the energy transition, the promotion of renewable sources entails the development of storage technologies to manage the mismatch between energy production and demand. In this scenario, the use of CAES (Compressed Air Energy Storage) technology enables
Juan Pous de la Flor, M. Cruz Castañeda, Manuel Arlandi, Fernando Ordás, Juan Pous Cabello   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

SL-LDA: LDA-Based Storage Location Assignment for Automated Warehouses Under MAPD Constraints

Systems
Storage location assignment in automated warehouses strongly affects order-processing efficiency. Existing co-occurrence-based approaches often rely on pointwise mutual information (PMI) statistics or direct frequency co-occurrence.
Tatsuto Ito, Taisei Hirayama, Naoki Hattori, Hiroki Sakaji, Itsuki Noda   +4 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Enhancing Warehouse Efficiency With Time Series Clustering: A Hybrid Storage Location Assignment Strategy

IEEE Access
In the rapidly evolving domain of e-commerce, effective warehouse management emerges as a critical factor for ensuring timely deliveries. This paper addresses the Storage Location Assignment Problem (SLAP) in e-commerce warehouses, a challenge ...
Hicham Kalkha, Azeddine Khiat, Ayoub Bahnasse, Hassan Ouajji   +3 more
doaj   +1 more source