Results 91 to 100 of about 738,126 (291)

Ontology-Based Search Procedure to Identify Tissue Samples in an Autopsy Archive: A Pilot Study

open access: yesApplied Medical Informatics, 2018
This study aimed to obtain a detailed record of all autopsy specimens analyzed in the Pathology Department of the Emergency Clinical Hospital for Children, Cluj-Napoca from 1974 to 2018, by using an ontology-based search procedure (OSP) intended to ...
Bogdan POP   +6 more
doaj  

Single-Tube Protocol for the Extraction of DNA or RNA from Paraffin-Embedded Tissues Using a Starch-Based Adhesive

open access: yesBioTechniques, 1996
We describe a method using an inexpenive craft glue to routinely isolate specific areas of tissue as small as 1 mm2 from paraffin sections. The tissue may be digested to release nucleic acid suitable for PCR or reverse transcription PCR.
Gavin R. Turbett   +3 more
doaj   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

open access: yesMolecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren   +4 more
wiley   +1 more source

Coleta de células progenitoras periféricas por aférese automatizada em equino: relato de procedimento

open access: yesArquivo Brasileiro de Medicina Veterinária e Zootecnia
The biotechnology used in tendon, bone and joint recoveries in Equine Medicine has improved in recent years. The most used are platelet rich plasma and stem cells from adipose tissue and bone marrow. However, recent studies have shown that stem cells can
J.O. Bernardo   +4 more
doaj   +1 more source

Estudo da fermentação alcoólica de soluções diluídas de diferentes açucares utilizando microcalorimetria de fluxo Study of the alcoholic fermentation of sugars diluted solutions through flow microcalorimetry

open access: yesQuímica Nova, 1997
The present study shows that with liquid nitrogen stored inocula of Saccharomyces cerevisiae, and standardized experimental procedure, flow microcalorimetry can be a valuable tool for monitoring in real time the alcoholic fermentation processes on line ...
Pedro L. O. Volpe
doaj   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

open access: yesMolecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh   +6 more
wiley   +1 more source

Building the distributed WPS-services execution environment [PDF]

open access: yesarXiv, 2015
The article describes the environment of WPS-based (Web Processing Service) distributed services, that uses scenarios in JavaScript programming language in order to integrate services with each other. The environment standardizes data processing procedures, stores all services-related information and offers the set of basic WPS-services.
arxiv  

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

open access: yesMolecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song   +13 more
wiley   +1 more source

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