Results 61 to 70 of about 720,761 (260)

Introduction

open access: yesGrounded Theory Review: An International Journal, 2013
Memos are neglected as a GT procedure. Memos are where the emergent concepts and theoretical ideas are generated and stored when doing GT analysis. They are a neglected procedure mostly in writing about doing GT, yet they are vital to GT analysis for ...
Barney G. Glaser
doaj  

The Advent of Semi-Elective Lung Transplantation—Prolonged Static Cold Storage at 10°C

open access: yesTransplant International
Since the early days of clinical lung transplantation the preservation of donor organs has become a fairly standardized procedure and most centers do follow similar processes. This includes the use of low-potassium high dextran flush solutions and static
K. Hoetzenecker   +4 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

A procedure for validating fixed-base driving simulators

open access: yesTransport, 2013
This paper aims to define a standard procedure for validating a fixed-base driving simulator to be used for road safety studies and in the automotive field for development of new vehicle-subsystems.
Massimo Losa   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Estudo da fermentação alcoólica de soluções diluídas de diferentes açucares utilizando microcalorimetria de fluxo Study of the alcoholic fermentation of sugars diluted solutions through flow microcalorimetry

open access: yesQuímica Nova, 1997
The present study shows that with liquid nitrogen stored inocula of Saccharomyces cerevisiae, and standardized experimental procedure, flow microcalorimetry can be a valuable tool for monitoring in real time the alcoholic fermentation processes on line ...
Pedro L. O. Volpe
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Experimental Conditions to Obtain Photopolymerization Induced Phase Separation Process in Liquid Crystal-Photopolymer Composite Materials under Laser Exposure

open access: yesInternational Journal of Polymer Science, 2014
We analyze the experimental conditions necessary to obtain a photopolymerization induced phase separation process inside liquid crystal-photopolymer composite materials.
Manuel Ortuño   +4 more
doaj   +1 more source

Contribution to studying the structural analysis of rocket fuel

open access: yesVojnotehnički Glasnik, 1995
A brief review of possible stresses and deformation of rocket fuel while stored, in its preparation for exploitation and in the course of exploitation. The procedure of its structural analysis is described and shortcomings of the calculation based on the
Miloš Čolaković
doaj   +1 more source

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