Results 71 to 80 of about 7,063,150 (343)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Hump Yard Track Allocation with Temporary Car Storage [PDF]

, 2010
In rail freight operation, freight cars need to be separated and reformed into new trains at hump yards. The classification procedure is complex and hump yards constitute bottlenecks in the rail freight network, often causing outbound trains to be ...
Bohlin, Markus, Flier, Holger, Maue, Jens, Mihalák, Matúš   +3 more
core   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

In-orbit calibration adjustment of the Nimbus-7 SMMR [PDF]

The procedure for converting raw antenna signals (counts) from the Nimbus-7 Scanning Multichannel Microwave Radiometer (SMMR) to microwave radiances is described.
Gloersen, Per
core   +1 more source

Optimized Pre-Compensating Compression

, 2018
In imaging systems, following acquisition, an image/video is transmitted or stored and eventually presented to human observers using different and often imperfect display devices.
Bruckstein, Alfred M., Dar, Yehuda, Elad, Michael   +2 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

An efficient quantum memory based on two-level atoms

, 2013
We propose a method to implement a quantum memory for light based on ensembles of two-level atoms. Our protocol is based on controlled reversible inhomogeneous broadening (CRIB), where an external field first dephases the atomic polarization and thereby ...
Iakoupov, Ivan, Sørensen, Anders S.
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Credibility and Authenticity of Digitally Signed Videos in Traffic

Promet (Zagreb), 2008
The paper presents the possibilities of insuring the credibilityand authenticity of the surveillance camera video by digitalsigning, using the public key infrastructure as part of interoperabletraffic and information system in the future ...
Ivan Grgurević, Adam Stančić, Pero Škorput   +2 more
doaj   +1 more source

Approximate quantum data storage and teleportation

, 2002
In this paper we present an optimal protocol by which an unknown state on a Hilbert space of dimension $N$ can be approximately stored in an $M$-dimensional quantum system or be approximately teleported via an $M$-dimensional quantum channel.
B. Schumacher, C. H. Bennett, D. Bruss, G. Vidal, K. Banaszek, K. Życzkowski, Klaus Mølmer, M. Horodecki, R. Jozsa, Thomas Laustsen   +9 more
core   +1 more source