Results 31 to 40 of about 365,063 (297)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Machine-Learning-Based Radar Quantitative Precipitation Estimation Using Intra-Hour Temporal Features from Dual-Polarization Observations

Remote Sensing
Hourly precipitation is a standard variable for hydrological applications, flood warning, and quantitative assessment of precipitation-related hazards. Weather radar provides high-frequency observations, but these sub-hourly measurements must be linked ...
Te Li, Xiaoran Zhuang, Xiaohua Wang, Yifei Xu, Zhicheng Ding, Mei Liu, Yuxuan Feng, Shangrongjie Dong   +7 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Foreseeing the reliability indexes of two-cascade thermo-electric cooling device in the mode of ΔTmax

Технологія та конструювання в електронній апаратурі, 2009
There has been offered a correlation model of reliability indexes for two-cascade TED of set design with basic meaningful parameters at successive electric connection of cascades.
V. P. Zaykov, L. A. Kinshova, V. F. Moiseev, L. D. Kazanghi, D. A. Klyuchnikov   +4 more
doaj  

Morphodynamic Evolution of Post-Nourishment Beach Scarps in Low-Energy and Micro-Tidal Environment

Journal of Marine Science and Engineering, 2021
Beach scarps are commonly associated with nourishment. Large and persistent beach scarps not only affect the performance of beach nourishment, but also are safety hazards to tourists.
Gen Liu, Hongshuai Qi, Feng Cai, Jun Zhu, Gang Lei, Jianhui Liu, Shaohua Zhao, Chao Cao   +7 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Other title: Annual report; Other title: Ohio Department of Transportation's Storm Water Management Program - ... annual report

, 2015
2014-; "Submitted to: Ohio Environmental Protection Agency."; Prepared by Ohio Department of Transportation and Gresham Smith and Partners.; "Permit No.
Storm Water Management Program (Ohio)
core   +1 more source

Forecasting of parameters of reliability two-cascade thermoelectrical cooling device in a mode Q0max

Технологія та конструювання в електронній апаратурі, 2009
The parities for an estimation of parameters of reliability two-cascade ТED of a various design depending on their basic parameters in a mode Q0max are received.
V. P. Zaykov, L. A. Kinshova, L. D. Kazanji, L. F. Khramova   +3 more
doaj  

A concentric tube catheter for endoluminal interventions, steered and imaged via magnetic resonance imaging

Communications Engineering
Two major challenges associated with robotic catheterization are, firstly, the provision of controllable degrees of freedom (DoFs) and, secondly, accessing feedback on the shape and pose of the catheter.
Peter Lloyd, Nikita Murasovs, Yael L. May, Alistair Bacchetti, Benjamin Calmé, Joshua Davy, Vittorio Francescon, James H. Chandler, Erica Dall’Armellina, Jurgen E. Schneider, Pietro Valdastri   +10 more
doaj   +1 more source