Results 191 to 200 of about 5,035 (244)

Functional super-resolution microscopy of fibers and polymers: convergence of artificial and biological systems at the nanoscale.

Nanoscale Horiz
Rao SJ, Gong X, Shahid MA, Liu Y, Mao H, Zhang Y.   +5 more
europepmc   +1 more source

Numerical modelling of the 1 July 2022 flooding event, Southwest Huvadhoo Atoll, Maldives: Implications for the future. [PDF]

Camb Prism Coast Futur
Masselink G, Poate T, Scott T, Roelvink F, McCall R.   +4 more
europepmc   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

Kilometer-scale convection-allowing model emulation using generative diffusion modeling. [PDF]

Sci Adv
Pathak J, Cohen Y, Garg P, Harrington P, Brenowitz N, Durran D, Mardani M, Vahdat A, Xu S, Kashinath K, Pritchard M.   +10 more
europepmc   +1 more source

Lewis‐Acid Engineering with Neodymium Promoters as Synergistic Nd‐Ni Dual Sites for Enhanced Urea Oxidation

Advanced Science, EarlyView.
The integration of rare‐metal neodymium centers to engineer Lewis acid sites with nickel centers is proposed as highly efficient UOR catalysts. ABSTRACT The sluggish kinetics of the urea oxidation reaction (UOR) are strongly associated with the high energy barriers required for the C‐N cleavage and N‐N coupling steps.
Mingfan Li, Jun Mei, Jiahao Zhao, Ruipeng Guo, Jing Shang, Ziyou Dong, Juan Bai, Qianqian Yao, Shixue Dou   +8 more
wiley   +1 more source

Trends in vertical wind velocity variability reveal cloud microphysical feedback. [PDF]

Nat Commun
Barahona D, Breen KH, Ngo D, Maciel FV, Patnaude R, Diao M.   +5 more
europepmc   +1 more source

Oxygen Vacancy‐Enriched Platinum Single‐Atom Nanozyme Wrapped in Nanoislands: Unlocking Catalytic Activity and Reprogramming Redox Microenvironment for Osteonecrosis Repair

Advanced Science, EarlyView.
CeO2‐x/Pt single‐atom nano‐island is constructed via low‐temperature reduction, featuring abundant oxygen vacancies and an island–sea structure. It delivers outstanding multi‐enzyme‐mimetic activity and ROS‐scavenging efficiency. Density functional theory reveals optimized electronic structures and reaction pathways.
Yang Zhu, Zehui Lv, Xuejie Cai, Penghui Wei, Dengliang Wang, Zhao Wang, Ruoying Wang, Yingjie Wang, Xingdong Yang, Yixin Bian, Jiawei Xu, Xisheng Weng, Liangfeng Wei   +12 more
wiley   +1 more source

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

Lactylation-driven PDLIM1/PDAP1 axis remodels the inflammatory landscape of acute lung injury: mechanistic insights and precision intervention. [PDF]

Front Immunol
Tang H, Song C, Correia G, Li C, Liu D, Zhou X.   +5 more
europepmc   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source