Results 161 to 170 of about 1,560,905 (327)

Insights into Genomic Dynamics and Plasticity in the Monkeypox Virus from the 2022 Outbreak. [PDF]

open access: yesInt J Mol Sci
Deiana M   +14 more
europepmc   +1 more source

ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment

open access: yesAdvanced Science, EarlyView.
ETV4 coordinates a dual transcriptional program by upregulating MET and asparagine synthetase (ASNS). The resulting asparagine (Asn) secretion acts as a metabolic signal, reprogramming hepatic stellate cells (HSCs) and primary cancer‐associated fibroblasts (CAFs) toward an inflammatory phenotype. These activated stromal cells release HGF to sustain the
Dujiang Fu   +14 more
wiley   +1 more source

A rare case of a retroperitoneal pregnancy: case report. [PDF]

open access: yesJ Surg Case Rep
Sokolov M   +11 more
europepmc   +1 more source

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

open access: yesAdvanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang   +15 more
wiley   +1 more source

Engineering scalable vascularized kidney organoids for in vivo glomerular filtration with human endothelial integration. [PDF]

open access: yesNPJ Biomed Innov
Tekguc M   +11 more
europepmc   +1 more source

Wooden Khanqahs of Kashmir (India) EWAP1001LG-STR-MAS001

open access: green
Endangered Wooden Architecture Programme
openalex   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

open access: yesAdvanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang   +10 more
wiley   +1 more source

Development and clinical validation of a stroke-specific Gait Deviation Index. [PDF]

open access: yesJ Neuroeng Rehabil
Sanz-Morère CB   +5 more
europepmc   +1 more source

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