Results 141 to 150 of about 1,954,896 (288)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

2D-STRAIGHT LINE PATH FOLLOWING AND NUMERICAL SIMULATION

Havacılık ve Uzay Teknolojileri Dergisi, 2018
In this paper, a two-dimensional-straight-line path following methodology for an unmanned aircraft is developed. With the developed algorithm, the unmanned aerial vehicle is made to converge to a predefined path, and then to follow a virtual target on ...
Zafer Öznalbant, Uğur Özdemir, Mehmet Ş. Kavsaoğlu   +2 more
doaj  

Differences in equine spinal kinematics between straight line and circle in trot. [PDF]

Sci Rep, 2021
Byström A, Hardeman AM, Serra Bragança FM, Roepstorff L, Swagemakers JH, van Weeren PR, Egenvall A.   +6 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Static Stiffness Analysis of a New Scissor-type Telescoping and Lifting Mechanism

Jixie chuandong, 2018
Combining hart straight-line mechanism with scissors mechanism,a new type of deployable model in straight-line motion which consists of revolute joint only is proposed.
Hao Gang, Chang Boyan, Li Wenqi
doaj  

Inter-Unit Consistency and Validity of 10-Hz GNSS Units in Straight-Line Sprint Running. [PDF]

Sensors (Basel), 2022
Chahal AK, Lim JZ, Pan JW, Kong PW.
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Kinematic Analysis During Straight Line Free Swimming in Horses: Part 2 - Hindlimbs. [PDF]

Front Vet Sci, 2021
Santosuosso E, Leguillette R, Vinardell T, Filho S, Massie S, McCrae P, Johnson S, Rolian C, David F.   +8 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Spectral Transition for Dirac Operators with Electrostatic δ -Shell Potentials Supported on the Straight Line. [PDF]

Integr Equ Oper Theory, 2022
Behrndt J, Holzmann M, Tušek M.
europepmc   +1 more source