Results 71 to 80 of about 543,240 (305)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Lead induced intergranular fracture in aluminum alloy AA6262 [PDF]

, 2003
The influence of lead on the fracture behavior of aluminum alloy AA6262 is investigated. Under certain conditions, the mode of fracture changes from transgranular microvoid coalescence to an intergranular mechanism. Three different intergranular fracture
Hosson, J.Th.M. De,, Wouters, O.,
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Recent Milestones in Unraveling the Full-Field Structure of Dynamic Shear Cracks and Fault Ruptures in Real-Time: From Photoelasticity to Ultrahigh-Speed Digital Image Correlation [PDF]

, 2020
The last few decades have seen great achievements in dynamic fracture mechanics. Yet, it was not possible to experimentally quantify the full-field behavior of dynamic fractures, until very recently.
Lapusta, N., Rosakis, A. J., Rubino, V.
core  

The mechanism of rate-dependent off-axis compression of a low fibre volume fraction thermoplastic matrix composite [PDF]

, 2017
This paper reports on the mechanism of rate-dependent off-axis compression of a unique unidirectional composite with unusually high matrix volume fraction of 65%.
Ageorges, Ambrose I. Akpoyomare, Bacon, Brown, Buckley, Bussac, C. Paul Buckley, Campbell, Carrillo, Cogswell, Fitoussi, Gibson, González, Govender, Gómez-del Ŕo, Harte, Hufenbach, Hull, Joseph, Koerber, Melro, Melro, Michael I. Okereke, Miller, Mulliken, Naik, Okereke, Park, Ree, Richeton, Siviour, Siviour, Tan, Taniguchi, van Rijswijk, Wu, Yoon, Zhao   +37 more
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Dynamic Compressive Strength and Failure of Natural Lake Ice Under Moderate Strain Rates at Near Melting Point Temperature

Latin American Journal of Solids and Structures
This paper presents a series of uniaxial compressive experiments on natural lake ice under moderate strain-rate in the range of 10−1 to 102 s−1 at −0.1 °C.
Chunfeng Qi, Jijian Lian, Qunan Ouyang, Xin Zhao   +3 more
doaj   +1 more source

A multiscale approach for modeling crystalline solids [PDF]

, 2001
In this paper we present a modeling approach to bridge the atomistic with macroscopic scales in crystalline materials. The methodology combines identification and modeling of the controlling unit processes at microscopic level with the direct atomistic ...
Cuitiño, Alberto M., Goddard, William A., III, Ortiz, Michael, Stainier, Laurent, Strachan, Alejandro, Wang, Guofeng, Çağin, Tahir   +6 more
core  

Crystal nucleation and cluster-growth kinetics in a model glass under shear

, 2010
Crystal nucleation and growth processes induced by an externally applied shear strain in a model metallic glass are studied by means of nonequilibrium molecular dynamics simulations, in a range of temperatures.
A. Dobreva, Anatolii V. Mokshin, D. Kashchiev, Jean-Louis Barrat, K. F. Kelton, V. M. Fokin   +5 more
core   +2 more sources