Results 71 to 80 of about 708,199 (311)

Effects of inbreeding and genetic modification on Aedes aegypti larval competition and adult energy reserves [PDF]

, 2010
Background Genetic modification of mosquitoes offers a promising strategy for the prevention and control of mosquito-borne diseases. For such a strategy to be effective, it is critically important that engineered strains are competitive enough to serve ...
Laura C Harrington, Kormaksson Matthias, Constantianus JM Koenraadt, Harrington Laura C, Koenraadt, C.J.M., Kormaksson, M., Harrington, L.C., Matthias Kormaksson, Koenraadt Constantianus JM   +8 more
core   +1 more source

Study on damage mechanical properties and energy evolution mechanism of rock under different freeze-thaw conditions

Zhongguo dizhi zaihai yu fangzhi xuebao
This study aims to investigate the damage mechanical properties of sandstone and its energy evolution behaviour under various freeze-thaw conditions, clarifying the synergistic effects of freeze-thaw cycle duration and the number of cycles on the rock ...
Daming ZHANG, Zhiyong HOU, Jiaming LIU, Zhiqiang WU   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Evolution mechanism of strain energy field and gravitational potential energy field of overlying rock under transient excitation of structure

Meitan xuebao
Revealing the aggregation and release mechanism of overlaying rock energy field is the theoretical basis for the prevention and cure of coal-rock dynamic disasters.
Shenghu LUO, Jiabo GAO, Zhuangzhuang YAN, Yongping WU, Panshi XIE, Gang HAN, Hongwei WANG, Chengyang TIAN, Tong WANG, Mingming SUN   +9 more
doaj   +1 more source

Recent crustal movement and great earthquakes in Qinghai-Tibet sub-plate

Geodesy and Geodynamics, 2011
Crustal movement and incremental-movement data observed repeatedly at GPS stations during 1999–2009 were analyzed to study the effect of two earthquakes of Ms8.1 and Ms8.0 that occurred in 2001 and 2008, respectively, in Qinghai-Tibet sub-plate and its ...
Guo Liangqian, Bo Wanju, Yang Guohua, Chen Juzhong, Guo He   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Evolution law of the activation and energy storage of fault with hard rock bridge under mining influence

Meitan xuebao
The presence of slide-resistant structures within faults alters the laws of energy accumulation and slip behavior, resulting in significant differences in the mechanisms of fault activation and instability compared to conventional understanding. To study
Jinguo LYU, Wenhe HAN, Xuepeng ZHANG, Yisheng PENG, Yishan PAN, Lianpeng DAI   +5 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

In-plane mixed-mode brittle fracture assessment of Harsin marble using HCSP specimen

Fracture and Structural Integrity
The primary objective of this manuscript is studying the effect of T-stress term (T) on the crack propagation angle (CPA) and fracture toughness of in-plane mixed mode loading by utilizing a generalized form of minimum strain energy density (SED ...
Z. Moqadaszadeh, H. Salavati, M. Rashidi Moghaddam   +2 more
doaj   +1 more source