Results 71 to 80 of about 4,650,029 (356)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Uniaxial stretch-induced axonal injury thresholds for axonal dysfunction and disruption and strain rate effects on thresholds for mouse neuronal stem cells

Journal of Biomechanical Science and Engineering, 2017
In this paper, the proposed study aims to achieve a better understanding of neuronal tolerance and contribute to the prediction of the secondary degeneration of diffuse axonal injury (DAI). Therefore, a uniaxial stretching device which subjected cultured
Evrim KURTOGLU, Hiromichi NAKADATE, Kazuhiro KIKUTA, Shigeru AOMURA, Akira KAKUTA   +4 more
doaj   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

A modified controlled cortical impact technique to model mild traumatic brain injury mechanics in mice.

Frontiers in Neurology, 2014
For the past 25 years, controlled cortical impact (CCI) has been a useful tool in traumatic brain injury (TBI) research, creating injury patterns that include primary contusion, neuronal loss, and traumatic axonal damage.
YungChia eChen, Haojie eMao, King H Yang, Ted eAbel, David F Meaney   +4 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Utilizing a Structural Mechanics Approach to Assess the Primary Effects of Injury Loads Onto the Axon and Its Components

Frontiers in Neurology, 2018
Diffuse axonal injury (DAI) occurs as a result of the transmission of rapid dynamic loads from the head to the brain and specifically to its neurons. Despite being one of the most common and most deleterious types of traumatic brain injury (TBI), the ...
Annaclaudia Montanino, Svein Kleiven
doaj   +1 more source

Injuries in the Chinese Arena Football League: American Versus Chinese Players. [PDF]

, 2018
Background: Arena football is an indoor version of American football played in indoor arenas on a smaller field with 8 players per team. Only 1 study has evaluated injury rates in arena football, and no study had compared 2 distinct cohorts of players ...
Chen, Shiyi, Chen, Tianwu, Feldman, Michael, Gillespie, Gunnar, Rubenstein, David, Singer, Scott, Wetzler, Austin, Wetzler, Merrick   +7 more
core   +2 more sources

Muscle strain injury vs muscle damage: Two mutually exclusive clinical entities

Translational Sports Medicine, 2019
Muscle strain injury and exercise‐induced muscle damage have been described as a continuum of injury whereby microtears (muscle damage) lead to muscle strain injury.
M. McHugh, T. Tyler
semanticscholar   +1 more source

The Economic Burden of Rheumatoid Arthritis in Low‐ and Middle‐Income Countries: Systematic Review and Meta‐Analysis

Arthritis Care &Research, Accepted Article.
Objective The aim of this systematic review was to synthesise the economic impact of rheumatoid arthritis (RA) on households, health systems, and society in low‐ and middle‐income countries (LMICs). Methods Electronic databases such as PubMed, Web of Science, and CINAHL were searched using keywords related to RA and cost of illness.
Tadesse Gebrye, Chidozie E.Mbada, Clara T.Fatoye, Faatihah Niyi‐Odumosu, Ushotanefe Useh, Zalmai Hakimi, Francis Fatoye   +6 more
wiley   +1 more source

Relationship between anatomical injury site of rectus femoris muscle strain and time taken to return to play in Japanese professional soccer players

Journal of Orthopaedic Surgery, 2022
Purpose The rectus femoris has three myotendinous or myoaponeurosis junctions and causes three types of muscle strain anatomically. We aimed to investigate the anatomical injury site of the rectus femoris muscle strain in professional soccer players as ...
Kengo Shimozaki, Junsuke Nakase, Kazuki Asai, Rikuto Yoshimizu, Mitsuhiro Kimura, Tomoyuki Kanayama, Yusuke Yanatori, Hiroyuki Tsuchiya   +7 more
doaj   +1 more source