Results 111 to 120 of about 2,821,004 (350)

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

open access: yesFEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan   +6 more
wiley   +1 more source

Projecting Low Dimensional Chaos from Spatio-temporal Dynamics in a Model for Plastic Instability

open access: yes, 2013
We investigate the possibility of projecting low dimensional chaos from spatiotemporal dynamics of a model for a kind of plastic instability observed under constant strain rate deformation conditions.
Ananthakrishna, G., Sarmah, Ritupan
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Avaliação da depressão miocárdica por meio do feature tracking bidimensional em cadelas com sepse

open access: yesArquivo Brasileiro de Medicina Veterinária e Zootecnia
RESUMO O objetivo deste estudo prospectivo foi analisar a função do ventrículo esquerdo de cadelas que apresentavam sepse ou não e diagnosticar a depressão miocárdica de forma precoce, por meio do feature tracking imaging bidimensional (FTI-2D).Vinte e ...
V.C. Figueiredo   +7 more
doaj   +1 more source

Mechanical strain induces growth of vascular smooth muscle cells via autocrine action of PDGF. [PDF]

open access: yes, 1993
The effect of cyclic mechanical strain on growth of neonatal rat vascular smooth muscle (VSM) cells were examined. Cells were grown on silicone elastomer plates subjected to cyclic strain (60 cycle/min) by application of a vacuum under the plates. A 48 h
Ives, HE   +4 more
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Crushing of Thin-Walled Strain Rate Sensitive Structures

open access: yesEngineering Transactions, 1981
A simplifying analysis is presented for evaluating the dynamic crushing strength of thin-walled structures subjected to compressive loading. Three major deformation mechanisms are distinguished and corresponding approximate expressions for the mean ...
T. Wierzbicki, W. Abramowicz
doaj  

Strain rate dependency of the properties of a unidirectional thermoplastic composite material [PDF]

open access: yes
This research work established the strain rate dependency of the the mechanical properties of a highly orientated glass fibre/thermoplastic composite lamina and validated a model for Computer Aided Engi­neering (CAE).
Papadakis, Nikolaos
core  

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

open access: yesFEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Realistic time-scale fully atomistic simulations of surface nucleation of dislocations in pristine nanopillars [PDF]

open access: yes, 2012
We use our recently proposed accelerated dynamics algorithm (Tiwary and van de Walle, 2011) to calculate temperature and stress dependence of activation free energy for surface nucleation of dislocations in pristine Gold nanopillars under realistic loads.
Tiwary, Pratyush, van de Walle, Axel
core  

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