Results 81 to 90 of about 325,690 (302)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

open access: yesFEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan   +6 more
wiley   +1 more source

Perspective—Supercapacitor-Powered Flexible Wearable Strain Sensors

open access: yesECS Sensors Plus, 2023
Currently and also in future, the flexible and wearable strain sensor would be in high demand due to its direct applications in biomedical health monitoring and other engineering applications.
C. Manjunatha   +4 more
doaj   +1 more source

Efficient large-scale multiplexing of fiber Bragg grating and fiber Fabry-Perot sensors for structural health monitoring applications [PDF]

open access: yes, 2006
Fiber Bragg gratings have been demonstrated as a versatile sensor for structural health monitoring. We present an efficient and cost effective multiplexing method for fiber Bragg grating and fiber Fabry-Perot sensors based on a broadband mode-locked ...
Cranch, Geoffrey A.   +2 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Ionogel-based flexible stress and strain sensors

open access: yesInternational Journal of Smart and Nano Materials, 2021
Ionogels is a kind of hybrid materials composed of ionic liquids (ILs) and solid polymer network matrix, has been extensively investigated in the most recent decade.
Gengrui Zhao   +9 more
doaj   +1 more source

Characterization of the modal parameters of composite laminates using innovative ultrathin polymer waveguide sensor foils [PDF]

open access: yes, 2018
The use of composite materials, like glass- and carbon- fiber reinforced polymers, is expected to increase exponentially in the coming years. Consequently, in order to monitor the structural health of these materials, the development of new sensing ...
Lamberti, Alfredo   +2 more
core   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Structure-Property Relationships in Graphene-Based Strain and Pressure Sensors for Potential Artificial Intelligence Applications

open access: yesSensors, 2019
Wearable electronic sensing devices are deemed to be a crucial technology of smart personal electronics. Strain and pressure sensors, one of the most popular research directions in recent years, are the key components of smart and flexible electronics ...
Zewei Luo   +11 more
doaj   +1 more source

Silicon strain sensors enable pressure measurement at cryogenic temperatures [PDF]

open access: yes, 1968
Miniature pressure transducers with diffused, heavily doped silicon strain-gage sensor elements, operates over a wide temperature range. Small thermal mass combined with close coupling between a metallic diaphragm and sensor elements minimizes ...
Bowman, R., Burns, J., Mc Lellan, W.
core   +1 more source

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