Results 91 to 100 of about 388,098 (307)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

The Philippines [PDF]

open access: yes, 2012
The Philippines is no stranger to geopolitics. It stood near the frontier of ideological struggles as the Cold War raged in the Asia-Pacific. Not only did American bases in the Philippines figure in the Korea and Vietnam conflicts, but the Philippine ...
Yujuico, Emmanuel
core   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

open access: yesFEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru   +6 more
wiley   +1 more source

Attualità psicopatologica del perturbante

open access: yesPhenomena Journal, 2019
The paper moves analysing the syntagma “inquietante estraneità” (uncanny, disturbing strangeness, translation of “inquietanteétrangeté”, “Unheimliche” French’s translation) and some others connected lexical forms.
Riccardo Galiani
doaj   +1 more source

What a Difference a Law Makes: Online Gun Sales in States With and Without Background Checks [PDF]

open access: yes, 2013
It is estimated that today there are about 4,000 websites dedicated to facilitating gun sales between private individuals. One of the largest of these sites -- Armslist.com -- essentially serves as an eHarmony or Craigslist for gun sales, connecting gun ...

core  

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

open access: yesFEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti   +3 more
wiley   +1 more source

Dinleri Paranteze Almak: PK Filmi Bağlamında Dinlerin Teolojik Kaynağı ve Sosyal İnşasının Fenomenolojik Bir Analizi

open access: yesİlahiyat Tetkikleri Dergisi, 2021
Cinema functions as a rich data store for researchers in understanding and interpreting unique characteristic components of a society such as language, culture, tradition, religion, etc.
Bahset Karslı, Ayşegül Türkeri
doaj  

Constructing the Hybrid Identity of the ‘Stranger’: The Case of Greek Immigrants in Canada

open access: yesPółrocznik Językoznawczy Tertium, 2018
The aim of our study is to examine the multiple ways Greek immigrants position themselves in terms of cultural identity. Recent approaches to immigrants’ cultural identities tend to employ the concept of transnationalism to account for their hybridity ...
Villy Tsakona   +3 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

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