Results 61 to 70 of about 388,098 (307)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

TPA: Fast, Scalable, and Accurate Method for Approximate Random Walk with Restart on Billion Scale Graphs

open access: yes, 2017
Given a large graph, how can we determine similarity between nodes in a fast and accurate way? Random walk with restart (RWR) is a popular measure for this purpose and has been exploited in numerous data mining applications including ranking, anomaly ...
Jung, Jinhong, Kang, U, Yoon, Minji
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

“A road that may lead nowhere”: J. M. Coetzee, Tayeb Salih, and the Hospitality of Vagrant Writing

open access: yesRevista de Filosofía Universidad Iberoamericana
This article argues that J.M. Coetzee’s writing, alienated from history yet unable to escape it, treats its own representations with suspicion and remains divided against itself.
Mike Marais
doaj   +1 more source

The wife as stranger in the family

open access: yesHTS Teologiese Studies/Theological Studies, 2019
The phenomenon of the stranger reveals that spatial relations are, on the one hand, only the condition and, on the other hand, the symbol of human relations. This article discusses the specific form of interaction of the wife (woman) as a stranger in the
Susara J. Nortjé-Meyer
doaj   +1 more source

Forcible Rapes and Sexual Assaults in Anchorage [PDF]

open access: yes, 2009
Originally published in the Alaska Justice Forum 20(4): 1, 9–11 (Winter 2004).This study examined the characteristics of all sexual assaults reported to the Anchorage Police Department from 2000 through 2003.
Rosay, André B.
core  

The sinner, the stranger, the sacrifice maker : an apocryphal autobiography [PDF]

open access: yes, 2015
textThis report serves as a kind of explanation and expansion upon the work I have taken on the past few months. It explores how the concepts of memory and perspective play a role in the narratives that we create.
Francel, Josef Nicholas
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Sexual Assaults in Anchorage [PDF]

open access: yes, 2009
Originally published in the Alaska Justice Forum 22(4): 2-3 (Winter 2006).This study examined the characteristics of all sexual assaults reported to the Anchorage Police Department from 2000 through 2003.
UAA Justice Center
core  

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