Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Stratégies cognitives et métacognitives dans les troubles de la personnalité
European Psychiatry, 2000 openaire +1 more source
Integrated Community-Clinic Model of Optimized Implementation Strategies to Increase Early Detection of Breast and Cervical Cancers in Kenya: Protocol for a Pragmatic Randomized Controlled Trial. [PDF]
JMIR Res ProtocGakunga R +8 more
europepmc +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Engaging patients throughout the continuum of implementation science and practice: adapted evidence mapping review and practical guide for clinicians and researchers. [PDF]
Health Res Policy SystSteeves L, Sampalli S, Ufcrquhart R.
europepmc +1 more source
Multiplicity, fluidity, dialogue and sharing: keywords to understand the complex dynamics between human learning and technology [PDF]
, 2016 Cesareni, Donatella, GRION, VALENTINA
core
Comment développer la créativité des études utilisant la théorie enracinée ? Choix épistémologiques et stratégies pratiques dans la quête de créativité. [PDF]
La théorie enracinée a été initialement développée pour proposer une alternative aux méthodes hypothético-déductives, qui formaient le courant majeur de la sociologie des années 1960, en visant à créer de nouvelles connaissances en se fondant sur les ...
Bandeira-de-Mello, Rodrigo +1 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Determinants and strategies for implementing guideline-adherent physiotherapy: a scoping review. [PDF]
BMJ OpenReiter NL, Rosen D, Erhart M, Vogel B.
europepmc +1 more source