Results 191 to 200 of about 3,906,096 (300)

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

Ambient temperature and exclusive breastfeeding: a nationwide cohort study in Brazil. [PDF]

Int J Epidemiol
Ribeiro-Silva RC, Cortes TR, Sacramento LS, Ribeiro LHL, Ranzani OT, Junior PC, Delgado D, Silveira IH, Vieira LS, Paixão ES, Costa PRF, Barreto ML.   +11 more
europepmc   +1 more source

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

Advanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu, Qishuai Chen, Yan Ma, Yang Liu, Xianing Dong, Wenjuan Wei, Jianxin Du, Shusheng Qiu, Maojin Tian, Peiqing Zhao   +9 more
wiley   +1 more source

cAMP-dependent modulation of giant depolarizing potentials by metabotropic glutamate receptors in the rat hippocampus

, 1995
SCIANCALEPORE M., STRATA, Fabrizio, STRATA F., CHERUBINI E., M Sciancalepore, SCIANCALEPORE M, CHERUBINI E, SCIANCALEPORE, MARINA, E Cherubini, Cherubini, Enrico, F Strata   +10 more
core   +2 more sources

Vertical stratification and seasonality of fruit-feeding butterfly diversity in a Neotropical dry forest. [PDF]

Naturwissenschaften
Nascimento BSD, de Araújo Silva G, de Jesus Araújo Pinto U, Macêdo JR, do Vale Beirão M, de Oliveira Silva J.   +5 more
europepmc   +1 more source

Appunti di Fisiologia del Neurone per le Piattaforme Sanitarie

, 2018
Fabrizio Strata
core  

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

Advanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li   +8 more
wiley   +1 more source

Temperature Induced Changes in Magnetic Susceptibility of Pittsburgh Coal Seam Strata

Journal American Society of Mining and Reclamation, 1994
openaire   +1 more source

A C‐Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti‐Psoriatic Activity via Microneedle Delivery

Advanced Science, EarlyView.
This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan, Xinyue Shao, Yuanchen Zhong, Xujie Sun, Lixuan Yin, Zongyan He, Tianqun Lang, Yuanchao Xie   +7 more
wiley   +1 more source

Stratodynamics: A New Theory of Layered Biological Response. [PDF]

Biology (Basel)
Ametaj BN.
europepmc   +1 more source