Results 221 to 230 of about 3,906,096 (300)

The CXCL5/CXCR2 Axis Attenuates Ferroptosis in Intrahepatic Cholangiocarcinoma Through the Positive Feedback Loop Between PTGS2 Transcriptional Activation and Neutrophil Recruitment

Advanced Science, EarlyView.
The CXCL5/CXCR2 axis directly inhibits ferroptosis in ICC cells by activating the NF‐κB/PTGS2 pathway. Meanwhile, the CXCL5/CXCR2 axis recruits N2 TANs, and the activated PTGS2 promotes the secretion of TNF‐α from the recruited N2 TANs via the CCL2/CCL7/CCR2 pathway, thereby activating the NF‐κB/PTGS2 axis and forming a positive feedback loop, which ...
Chanqi Ye, Kefeng Lin, Shuyao Yang, Yan Zhang, Wenli Gao, Jiaqi Chen, Ying Dong, Rui Bai, Yang Tian, Minghao Wang, Zhijun Yuan, Yuxiao Ma, Yuqin He, Ruyin Chen, Wenguang Fu, Qi Jiang, Qiong Li, Jian Ruan   +17 more
wiley   +1 more source

The impact of elevation and population density on dengue incidence and force of infection across the Philippines: Implications for climate-adapted surveillance. [PDF]

PLoS Negl Trop Dis
Sy AK, Biggs J, Chowdhury SK, Quinones MA, Salazar FV, Jones-Warner W, Ashall J, Sucaldito MNL, Cutiongco-de la Paz E, Capeding MRZ, Padilla CD, Villanueva SYAM, Hibberd ML, Hafalla JCR.   +13 more
europepmc   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source

Functional and Trophic Structuring of Micronektonic Fishes in the Northeast Atlantic. [PDF]

Ecol Evol
Thibault H, Ménard F, Roudaut G, Lebourges-Dhaussy A, Cherel Y, Ariza A, Nolé Eduardo L, Martini S.   +7 more
europepmc   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Heat-related mortality attributable to climate change across age and sex in the Netherlands, 1971–2019

Finnemann A, Dablander F, Wiers R, Haslbeck J.   +3 more
europepmc   +1 more source

Diurnal variations of fever in children: results from an app-based observational study. [PDF]

BMC Pediatr
Beerenbrock Y, Möhler R, Rathjens L, Jenetzky E, Martin DD.   +4 more
europepmc   +1 more source

The Relation between Temperature of Air Raised by Heat Flow from Gob and Strata Temperature at Longwall Face

Journal of the Mining Institute of Japan, 1980
openaire   +2 more sources

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source

Accelerating Burden of Hypertensive Heart Disease in Low- and Lower-Middle-SDI Countries, 1990-2023: The Contribution of Cold Temperature Exposure. [PDF]

Ann Glob Health
Ruan M, Zhang R, Wei J, Niu T, Wang S, Shi W, Yang G, Dong T.   +7 more
europepmc   +1 more source