Results 91 to 100 of about 7,833 (250)

Near‐Infrared Fluorescent PROTAC Enables Theranostic Imaging and Selective Tau Degradation in Alzheimer's Disease

Advanced Science, EarlyView.
Here, we report a novel NIR fluorescent PROTAC platform that enables real‐time imaging and targeted degradation of Alzheimer's p‐Tau. Our lead compound effectively clears p‐Tau, reduces APP/Aβ, and alleviates cognitive deficits in AD mice. This work demonstrates a theranostic strategy for visualizing degradation and developing next‐generation AD ...
Ziwei Ren, Qian Yue, Ning Gao, Qiu‐Lian Hao, Yan Huo, Chuchu Li, Xinyue Leng, Lu‐Lu Sun, Maggie Pui Man Hoi, Hai‐Hao Han, Mingliang Ma, Xu‐Wen Li   +11 more
wiley   +1 more source

Performance of Multipartner Strategic Alliances

, 2015
This chapter focuses on the phenomenon of multipartner strategic alliances (MSAs), explaining how differences in partners’ collaborative strategies lead to performance differences. In order to do so, we conducted an exploratory case study on a research and development (R&D) consortium, accounting for the multifaceted nature of value creation and ...
Estrada Vaquero, Isabel, Martin-Cruz, Natalia   +1 more
openaire   +2 more sources

Spatiotemporal Thermal Modulation and Patterning using a Programmable 1024 Element Microheater Array

Advanced Science, EarlyView.
Programmable microheater arrays are essential for a variety of applications. However, large arrays have thus far not been realized. We introduce a programmable 32×$\times$32 microheater array consisting of heating elements – each smaller than 300 μm$\umu{\rm m}$.
Rahul Goyal, Jang‐Hwan Han, Sadaf Pashapour, Peer Fischer   +3 more
wiley   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Industrial Alliances for the Energy Transition: Harnessing Business Power in the Era of Geoeconomics

Politics and Governance
In a context of rising geoeconomic competition, the EU is embracing stronger industrial interventionism to address societal challenges and reduce external dependencies in strategic sectors.
Riccardo Bosticco, Anna Herranz‐Surrallés   +1 more
doaj   +1 more source

Reversible, Chemically Gated FRET via Ligand‐Activated Acceptors

Advanced Science, EarlyView.
Fluorogen binding turns the compact FAST tag into a tunable FRET acceptor, with ligand chemistry programming spectral overlap and excited‐state lifetimes. Fluorescence‐lifetime imaging reads out energy transfer through the shortened donor lifetime, while simply adding or washing out the dye switches FRET on and off, reversibly mapping the supramodular ...
Nivedita Singh, Smruti Ranjan Nayak, Sanjay Kumar Mohanty, Aishwarya Hanumantharaju, Amala Shaju, Mini Jose, Aravind Penmatsa, Deepak Nair   +7 more
wiley   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Alianças estratégicas no setor de autopeças: o caso forjas brasileiras

Cadernos EBAPE.BR
O presente artigo tem como objetivo contribuir aos estudos sobre a gestão das empresas inseridas em alianças, focando na questão de suas implicações estratégicas, à luz das suas características relacionais. Concentra-se no caso de Forjas Brasileiras, uma
Alexandre Celaro, T. Diana L. van Aduard de Macedo-Soares   +1 more
doaj   +1 more source

Water‐Soluble Luminescent Trityl Radical for Fluorescence/Magnetic Resonance Dual‐Modal Imaging Probe

Advanced Science, EarlyView.
Stable water‐soluble luminescent tris(2,4,6‐trichlorophenyl)methyl (TTM) radicals, TTM‐trisTP3B and TTM‐trisTP9B, were designed and successfully synthesized. They exhibited deep‐red emissions and high photostability in water. TTM‐trisTP3B exhibited dual functionality as a fluorescence imaging (FI) probe and a magnetic resonance imaging (MRI) contrast ...
Kosuke Anraku, Satoshi Okada, Akira Sumiyoshi, Kenshiro Matsuda, Kazuhiro Nakamura, Takuya Hosokai, Ken Albrecht   +6 more
wiley   +1 more source

Thickness‐Gradient Liquid Metal Connectors for Seamless Electrophysiological Sensors

Advanced Science, EarlyView.
Thickness‐gradient liquid metal interfaces with elastomeric substrates enable seamless integration between ultrathin skin‐conformal electrodes and external interconnects. The mechanically compliant connector reduces interfacial mismatch and supports stable ECG/EMG monitoring under bending and motion.
Jinyoung Kim, Jaejun Lee, Christopher E. Tabor, Vladimir V. Tsukruk   +3 more
wiley   +1 more source