Results 161 to 170 of about 1,420,289 (339)
Interfirms Collaboration - the Basis for Interorganizational Innovation [PDF]
In the current economic environment, interfirm collaboration for innovation is increasingly present because of the opportunities for growth and development that it offers to the partners involved and it is included in the company’s strategy, designed ...
Raluca ZOLTAN
core
GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer
Advanced Science, EarlyView.Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello +10 more
wiley +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Contractual heterogeneity in strategic alliances. [PDF]
We investigate firms' alliance design choices by examining alliances as multifaceted contractual forms. The analysis explores the contractual heterogeneity underlying alternative governance structures for alliances, the bundling of different contractual ...
Ariño, Africa, Reuer, Jeffrey J.
core
Advanced Science, EarlyView.Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv +29 more
wiley +1 more source
LAS ALIANZAS ESTRATÉGICAS INTERNACIONALES. EL IMPACTO DEL ORIGEN DEL SOCIO EN LA RELACIÓN
Revista de Estudios Empresariales. Segunda Época, 2007 The strategic alliances are a phenomenon that has experienced a great increase in the last years. The reasons are the changes that the international environment is producing. That is to say, the globalization process determines the creation of alliances,
Rosario García Cruz +1 more
doaj
Growth strategies and value creation: what works best for stock exchanges? [PDF]
In recent years, demutualized stock exchanges have been increasingly engaging in M&A and alliance activities. To examine the effect of these growth strategies on exchange shareholders’ value creation, we focus on 14 public stock exchanges and investigate
Hasan, Iftekhar +2 more
core
Advanced Science, EarlyView.We demonstrate a hybrid WS2/CuInP2S6/graphene heterostructure integrated on a silicon nitride microring resonator for non‐volatile optical phase modulation with ultra‐low energy consumption and low insertion loss. While CIPS alone does not provide efficient optical index modulation, the engineered proposed device structure converts ferroelctric domain ...
Lalit Singh +10 more
wiley +1 more source