Results 171 to 180 of about 29,308,301 (338)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Localized Hydrogel-Based Therapeutics: A Strategic Approach to Mitigating Postoperative Recurrence in Breast Cancer. [PDF]

Polymers (Basel)
Kainat K, Saif Ur Rahman M, Shoaib M, Xu S.   +3 more
europepmc   +1 more source

A strategic approach to social sustainability - Part 1: exploring the social system

, 2017
M. Missimer, K. Robért, Göran Broman
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Digital health: A university led strategic approach to transform healthcare in Salford, UK

International Journal of Integrated Care, 2014
Shahid Ali
doaj   +3 more sources

Boosting T cell antioxidant capacity: A strategic approach to overcome immunosuppression in solid tumors. [PDF]

Redox Biol
Liu F, Pang Y, Wang L, Dimkpa CK, Zhang B, Liang J.   +5 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Selection of Promising Candidates for Herbal Veterinary Medicinal Products: A Strategic Approach. [PDF]

Planta Med
Arsenijević J, Renouard C, Bacova K, Bilgi C, Cousin C, Di Loria A, Drobac M, Dungen FVD, Efthimiou G, Foitova I, Hunyadi A, Jacques AM, Kosakowsk O, Kristofova R, Laborieux L, Marčetić M, Pogány Simonova M, Semen Z, Styczyńska S, Schlittenlacher T, Vargas-Murga L, Walkenhorst M, Yurdakok-Dikmen B, Mendel M.   +23 more
europepmc   +1 more source

A Strategic Approach to Social Sustainability - Part 2 : A Principle-based Definition

, 2017
M. Missimer, K. Robért, Göran Broman
semanticscholar   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source