Results 141 to 150 of about 127,771 (308)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A Unifying Impossibility Theorem [PDF]
This paper considers social choice correspondences assigning a choice set to each non-empty subset of social alternatives. We impose three requirements on these correspondences: unanimity, independence of preferences over infeasible alternatives and ...
Shino Takayama, Priscilla Man
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Framing for incentive compatibility in choice modelling
The incentives that motivate respondents to reveal their preferences truthfully have been a long-standing area of research in the non-market valuation literature.
Mazur, Kasia, Bennett, Jeffrey W.
core
The cognitive perspective in strategic choice [PDF]
, 2018 This paper examines to what degree organizations use strategies that focus on maximizing shareholder value (Theory E) or if they use strategies emphasizing the development of organizational capability (Theory O).
Selart, Marcus, Midtgård, Kenneth
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
, 2013 Finding that the European Neighbourhood Policy (ENP) currently lacks a strategic vision that would offer states in the southern Mediterranean substantial returns in exchange for making tough reforms, this CEPS Commentary suggests that this weakness can ...
Van Vooren, Bart, Blockmans, Steven.
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Competition and the Strategic Choice of Managerial Incentives: the Relative Performance Case
In this paper we study the role of market competitiveness in a strategic delegation game in which owners delegate output decisions to managers interested in the firm's relative performance.
Chirco, Alessandra +2 more
core
Methods to Identify Strategic Alternatives of Development of the Organization
Управленческое консультирование, 2018 Modern methodological support of the strategic management of the company offers a wide range of methods to identify possible areas of development of the organization. There are two approaches: marketing for the development of the product, and management,
Juriy Mikhailovich Tsygalov +1 more
doaj