Results 11 to 20 of about 17,299 (256)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Microbes vary strategically in their metalation of mononuclear enzymes

Proceedings of the National Academy of Sciences
Studies have determined that nonredox enzymes that are cofactored with Fe(II) are the most oxidant-sensitive targets inside Escherichia coli . These enzymes use Fe(II) cofactors to bind and activate substrates. Because of their solvent exposure, the metal can be accessed and oxidized by reactive oxygen species ...
Sanjay Kumar Rohaun, Ramakrishnan Sethu, James A. Imlay   +2 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Strategic metals recovery from wastes [PDF]

, 2017
The recovery of different types of metals from wastes has had a spreading interest in the last years. One reason is that wastes, and in particular e-waste, contain metals which are considered strategic.
Cerchier, Pietrogiovanni
core  

C-Alkyl-bis-phosphoryl chelating systems for the potential recovery of strategic metals

, 2020
International audienceMethylene-bis-phosphonic acid and derivatives are used as complexing agents, diagnostics, therapeutics and show interesting virustatic properties.
Babouri, Rachida, Pirat, Jean-Luc, Volle, Jean-Noël,, Ilagouma, Amadou Tidjani, Dougourikoye, Abdoul Razak Halidou, Virieux, David, Volle, Jean-Noël, Null   +6 more
core   +1 more source

Critical and Strategic Metal Resources of Greece

Bulletin of the Geological Society of Greece
Greece has a large number of critical and strategic metal resources. The proven and indicated reserves of aluminum amount to 2.5 mt and their gross value €5.075 b. Those of chromium amount to 1.2 mt with gross value €4.320 b, while of cobalt are 129 th. t with gross value €3.348 b.
Ananias Tsirambides, Anestis Filippidis
openaire   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Geology and occurrence of critical strategic metals (chromium, cobalt, manganese, and platinum) in Wyoming

, 1987
Geology and occurrence of critical strategic metals (chromium, cobalt, manganese, and platinum) in ...
W.D. Hausel (10069834)
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source