Results 71 to 80 of about 1,961,582 (287)

Indo-US Strategic Partnership: Implications for Pakistan

open access: yesPolicy Perspectives, 2018
In the scheme of American grand strategy for the ‘new world order’, India has emerged as the most powerful regional ally. The emerging “strategic partnership” between the US and India is based on a shared view for democracy and concerns about the threat ...
Sadaf Farooq, Sadia Kazmi, Javaria Javed
doaj   +1 more source

Cross-CRP Analysis of Partnership Strategies in the 2017-2022 CRP2 [PDF]

open access: yes, 2023
This brief provides a summary analysis of how well the CGIAR Research Programs (CRPs) are planning the design and implementation of their partnership strategies, and how the strategic partnership activities contribute to the outputs and outcomes of the ...
CGIAR Independent Science and Partnership Council
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Strategic Partnerships at Local Level: Just Rhetoric or a Way Forward? [PDF]

open access: yes
This paper explores the issues around the recent developments of Strategic Partnerships at Local Level based on the initiatives for community regeneration and economic development introduced by the New Labour in order to achieve urban renaissance.
Apostolakis, Christos
core   +5 more sources

The undoing of a unique relationship? Peace and security in the EU-South Africa Strategic Partnership [PDF]

open access: yes, 2017
When the EU and South Africa acceded to a strategic partnership, they expanded into new areas of partnership. One of these areas was peace and security, which is the focus of this article.
Haastrup, Toni; id_orcid   +2 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

The Gulf Cooperation Council as a New Regional Power: Time for the EU to Propose a Strategic Partnership. Bruges Regional Integration & Global Governance Papers 3/2012, November 2012 [PDF]

open access: yes, 2012
The Gulf Cooperation Council (GCC) is a de facto regional power in the Arab world. Its role has been crucial in some of the outcomes of the Arab Spring. The GCC countries have been very pragmatic in dealing with the uprisings, avoiding any revolutionary ...
Giardullo, Cono
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

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