Results 51 to 60 of about 2,432,441 (210)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Cross-CRP Analysis of Partnership Strategies in the 2017-2022 CRP2 [PDF]
, 2023 This brief provides a summary analysis of how well the CGIAR Research Programs (CRPs) are planning the design and implementation of their partnership strategies, and how the strategic partnership activities contribute to the outputs and outcomes of the ...
CGIAR Independent Science and Partnership Council
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
The undoing of a unique relationship? Peace and security in the EU-South Africa Strategic Partnership [PDF]
, 2017 When the EU and South Africa acceded to a strategic partnership, they expanded into new areas of partnership. One of these areas was peace and security, which is the focus of this article.
Haastrup, Toni; id_orcid +2 more
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Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Partnership in implementation of the Structural Funds in Poland: 'shallow' adjustment or internalization of the European mode of cooperative governance? [PDF]
The ongoing debate about the future of EU cohesion policy includes the voices of critics questioning its effectiveness, as well as those of proponents praising its praising its contribution to regional development policy.
Marcin Dabrowski
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The Gulf Cooperation Council as a New Regional Power: Time for the EU to Propose a Strategic Partnership. Bruges Regional Integration & Global Governance Papers 3/2012, November 2012 [PDF]
, 2012 The Gulf Cooperation Council (GCC) is a de facto regional power in the Arab world. Its role has been crucial in some of the outcomes of the Arab Spring. The GCC countries have been very pragmatic in dealing with the uprisings, avoiding any revolutionary ...
Giardullo, Cono
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Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Repository Strategic Management Business Journal
Strategic Management Business Journal is a forum for researchers in management science, especially in creating the effect of improving organizational performance in human resource management, financial management, and marketing management.
journal, strategic management business
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