Results 61 to 70 of about 1,561,114 (282)

The EU–India strategic partnership: neither very strategic, nor much of a partnership

Cambridge Review of International Affairs, 2015
While formally labelled as ‘strategic’, the European Union (EU)–India partnership is more often than not described as ‘lukewarm’ and ‘reluctant’. Thus, by process-tracing the EU–India relationship, this article reveals the significance of 1999 as a crucial point that has urged both Brussels and New Delhi to significantly alter both their outlook on ...
openaire   +4 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Strategic partnerships to improve surgical care in the Asia-Pacific region: proceedings. [PDF]

BMC Proc, 2023
Qin RX, Stankey M, Jayaram A, Fowler ZG, Yoon S, Watters D, Gelb AW, Park KB.   +7 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Research & Strategic Partnerships: Quarterly Review, Volume 3, Issue 1 [PDF]

, 2016
To commemorate the opening of Tilikum Crossing and the launch of this dynamic new district, this issue of the RSP Quarterly Review focuses on PSU collaborations with OHSU, OMSI, and the City of Portland.
Portland State University. Research & Strategic Partnerships
core   +1 more source

Universities and Communities: The Need for a Real Strategic Partnership

Transylvanian Review of Administrative Sciences
Strategic partnerships between universities and intelligent communities are essential for address­ing rapid, profound societal changes. Communities benefit from access to educated human capital, research, and global connections, while universities gain ...
Călin E. Hințea
doaj   +1 more source

Strategic Goals of Energy Security Policy of the Federal Republic of Germany

Politeja, 2017
The aim of the article is to analyse the strategic goals of energy security of the Federal Republic of Germany in the context of foreign policy. The author hypothesizes that achieving the strategic goals of the energy policy of the Federal Republic of ...
Mariusz Ruszel
doaj   +1 more source

A Game Theory Approach for Strategic Partnerships in Academic Medicine. [PDF]

Perm J, 2023
Wei V, Netski AL, Krakovitz PR, Kahn MJ.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source