Results 41 to 50 of about 1,233,004 (294)

International university-university technology transfer: Strategic management framework

Technological forecasting & social change, 2018
International technology transfer between universities is an emerging phenomenon and contributes to the socio-economic development of regions and countries.
Kevin De Moortel, Thomas Crispeels
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Exploring tourism experiences: comparative trends and hotspots in Chinese and American research

Cogent Business & Management
This paper explores tourism experiences through a comparative analysis of research trends and hotspots in China and the United States. Using CiteSpace software, it analyzes relevant literature from 1 January 2004 to 10 May 2024. The research reveals that
Zhang Yaling, Asad Ur Rehman, Ihtisham Ullah, Ayesha Nawal, Kashif Hussain   +4 more
doaj   +1 more source

Strategic Management of Technology

Review of Professional Management- A Journal of New Delhi Institute of Management, 2011
The paper has been developed in the following way: • To identify the key themes of managing strategic innovation and change; • To study the technological factors which are responsible for Innovation and Change; • To understanding both of the existing technological advances and the probable future advances that can affect the organization's ...
openaire   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Practice and Reflection on Scientific and Technological Strategic Intelligence [PDF]

Nongye tushu qingbao xuebao
[Purpose/Significance] The new round of technological revolution and industrial transformation is accelerating, and its impact on national development and security is becoming deeper and wider.
LENG Fuhai
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A Framework for the Strategic Management of Science & Technology Parks

Journal of Technology Management & Innovation, 2016
Science and technology parks (STPs) have been playing an increasingly influential role in the stimulation and growth of the knowledge economy. However, the spread of STPs faces relevant challenges, such as the development of robust performance management
Juliane Ribeiro, Agnaldo Higuchi, Marcelo Bronzo, Ricardo Veiga, Adriana de Faria   +4 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source