Results 41 to 50 of about 151,581 (308)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Strategic Management of Technology

Review of Professional Management- A Journal of New Delhi Institute of Management, 2011
The paper has been developed in the following way: • To identify the key themes of managing strategic innovation and change; • To study the technological factors which are responsible for Innovation and Change; • To understanding both of the existing technological advances and the probable future advances that can affect the organization's ...
openaire   +1 more source

'Legitimation' and 'development of positive externalities' : Two key processes in the formation phase of technological innovation systems

, 2008
Responding to the climate change challenge requires a massive development and diffusion of carbon neutral technologies and, thus, emergence and growth of new socio-technical systems.
Sandén, Björn, Jacobsson, Staffan,, Sandén, Björn,, Jacobsson, Staffan, Bergek, Anna,, Bergek, Anna   +5 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Technology Transfer Capability: development dynamics in higher education institutions

BBR: Brazilian Business Review, 2019
This paper aims to explain how the development dynamics of technology transfer capability occurs in Brazilian public higher education institutions. This study was guided by the dynamic capabilities perspective and some technology transfer models found in
Cleverton Rodrigues Fernandes, André Gustavo Carvalho Machado   +1 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Exploring tourism experiences: comparative trends and hotspots in Chinese and American research

Cogent Business & Management
This paper explores tourism experiences through a comparative analysis of research trends and hotspots in China and the United States. Using CiteSpace software, it analyzes relevant literature from 1 January 2004 to 10 May 2024. The research reveals that
Zhang Yaling, Asad Ur Rehman, Ihtisham Ullah, Ayesha Nawal, Kashif Hussain   +4 more
doaj   +1 more source

Information Technology Strategic Planning towards a Contingency Approach [PDF]

Muṭāli̒āt-i Mudīriyyat-i Ṣan̒atī, 2005
Rapid development of applications of information technology in the third millennium and its enormous effects on the value chain of enterprises has imposed a strategic nature to this kind of technology.
Mohammad Reza Taghva, Hadi Esmaeilzadeh, Amir Mohtarami   +2 more
doaj