Results 111 to 120 of about 5,271,281 (317)
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Doping Prevalence among U.S. Elite Athletes Subject to Drug Testing under the World Anti-Doping Code
Sports Medicine - OpenBackground Determining the prevalence of doping within an elite athlete population is challenging due to the extreme sensitivity of the topic; however, understanding true doping prevalence is important when designing anti-doping programs and measuring ...
Ann Kearns Davoren +6 more
doaj +1 more source
The final push strategy to eliminate leprosy as a public health problem: questions and answers
, 2002 openalex +1 more source
Journal of Combinatorial Theory, Series A, 1985 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Human in vitro models for Fabry disease: new paths for unravelling disease mechanisms and therapies
Journal of Translational MedicineFabry disease is a multi-organ disease, caused by mutations in the GLA gene and leading to a progressive accumulation of glycosphingolipids due to enzymatic absence or malfunction of the encoded alpha-galactosidase A.
Carla Borisch +3 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
SGLT2 inhibitors attenuate endothelial to mesenchymal transition and cardiac fibroblast activation
Scientific ReportsBeneficial effects of sodium glucose co-transporter 2 inhibitors (SGLT2is) in cardiovascular diseases have been extensively reported leading to the inclusion of these drugs in the treatment guidelines for heart failure.
Kevin Schmidt +10 more
doaj +1 more source