Results 171 to 180 of about 3,720,097 (267)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Optimized Mass Spectrometry to Uncover M. tuberculosis Biomarkers in Extracellular Vesicles From Asymptomatic Tuberculosis Patients. [PDF]

J Infect Dis
Nieto Ramirez LM, Shelton K, Belisle JT, Diaz G, Tameris M, Naidoo K, Churchyard G, Scriba T, Walzl G, Sterling TR, Hadley K, Mulenga H, Hatherill M, Dobos KM.   +13 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Author Correction: Examining the unsustainable relationship between SDG performance, ecological footprint and international spillovers

Scientific Reports
Mustafa Moinuddin, Simon Høiberg Olsen
doaj   +1 more source

Simulating the impact of preventive strategies for older persons' emergency care demands on health care utilisation, Amsterdam as Dutch use case. [PDF]

Age Ageing
Smeekes OS, de Boer TR, Willems HC, van der Mei RD, Buurman BM.   +4 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Tackling Anxiety- and Stress-Related Freezing of Gait in People With Parkinson's Disease (TACKLING-FOG): Study Protocol for a Randomized Controlled Trial. [PDF]

Eur J Neurosci
Vissers G, Tosserams A, Duits AA, van der Heide A, Bloem BR, Helmich RC, Young WR, Nonnekes J.   +7 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Process and Strategies for Implementing an Antenatal Psychosocial Clinical Decision Support System Within an Inter-Organisational Care Context: The Born in Belgium Professionals Platform. [PDF]

Healthcare (Basel)
Amuli K, Decabooter K, Germanes C, Van Parys AS, Verschelde S, Saey E, Moulin M, Cornu P, Beeckman K.   +8 more
europepmc   +1 more source