Results 51 to 60 of about 19,566,468 (347)

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

Cell, 2019
Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The presence of extracellular β-amyloid deposition as neuritic plaques and intracellular accumulation of hyperphosphorylated tau as neurofibrillary tangles remains the primary
J. Long, D. Holtzman
semanticscholar   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Politeness Strategies in 2014 Presidential Debates Between Joko Widodo and Prabowo Subianto [PDF]

, 2015
This study analyzed the politeness strategies employed by Joko Widodo andPrabowo Subianto in 2014 Presidential Debates. This study used descriptivequalitative method.
Ownie, M. D. (Marischa)
core  

A refined compilation of implementation strategies: results from the Expert Recommendations for Implementing Change (ERIC) project

Implementation Science, 2015
BackgroundIdentifying, developing, and testing implementation strategies are important goals of implementation science. However, these efforts have been complicated by the use of inconsistent language and inadequate descriptions of implementation ...
B. Powell, T. Waltz, M. Chinman, L. Damschroder, Jeffrey L. Smith, M. Matthieu, E. Proctor, J. Kirchner   +7 more
semanticscholar   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

A circular RNA derived from the ryanodine receptor 2 locus controls cardiac hypertrophy and calcium handling

Cellular and Molecular Life Sciences
Heart failure (HF) is a leading cause of mortality worldwide, characterized by structural and functional alterations that result in reduced cardiac function. During the progression of HF, cardiomyocytes undergo profound remodeling – including development
Wen Pan, Hannah J. Hunkler, Shambhabi Chatterjee, Dongchao Lu, Isabelle Riedel, Anika Gietz, Ke Xiao, Maximilian Fuchs, Dimyana Neufeldt, Theresia Kraft, Cheng-Kai Huang, Sarah Cushman, Anne Bührke, Arne Schmidt, Elisa Mohr, Natalie Weber, Christian Bär, Thomas Thum   +17 more
doaj   +1 more source

Hyperparameters and tuning strategies for random forest [PDF]

WIREs Data Mining Knowl. Discov., 2018
The random forest (RF) algorithm has several hyperparameters that have to be set by the user, for example, the number of observations drawn randomly for each tree and whether they are drawn with or without replacement, the number of variables drawn ...
Philipp Probst, Marvin N. Wright, A. Boulesteix   +2 more
semanticscholar   +1 more source

Strategy Logic

Information and Computation, 2007
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Chatterjee, K, Henzinger, TA, Piterman, N   +2 more
openaire   +2 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

The Communication Strategies Employed By Male And Female Students Of English Department Of Stain Gajah Putih Takengon [PDF]

, 2018
In an educational world, communication is seen as a necessity,as education is a communication process. When communicating, the EFL students often face many obstacles that make them use communication strategies. However, in the same time, theyare required
Susidamaiyanti, S. (Susidamaiyanti)
core