Results 81 to 90 of about 5,271,281 (317)

PB2470: VENO-OCCLUSIVE DISEASE (VOD)/SINUSOIDAL OBSTRUCTION SYNDROME (SOS) INCIDENCE AND TREATMENT TRENDS INSIGHTS FROM LATEST SYSTEMATIC REVIEW OF CASE REPORTS (2018-2023)

HemaSphere, 2023
Saurabh Aggarwal, Sushil Kumar, Amrit Bela, Ozlem Topaloglu   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Circular RNA circIGF1R controls cardiac fibroblast proliferation through regulation of carbohydrate metabolism

Scientific Reports
Excessive fibroblast proliferation and metabolic reprogramming are hallmarks of pathological cardiac remodeling, contributing significantly to impaired cardiac function. This study investigates the role of circular RNAs (circRNAs) in fibroblast metabolic
Arne Schmidt, Kevin Schmidt, Sonja Groß, Dongchao Lu, Ke Xiao, Dimyana Neufeldt, Sarah Cushman, Nele Lehmann, Sabrina Thum, Angelika Pfanne, Annette Just, Andreas Pich, Alexander Heinz, Karsten Hiller, Hannah Jill Hunkler, Wilson Lek Wen Tan, Roger Foo, Christian Bär, Thomas Thum, Mira Jung   +19 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Ecological Civilization Construction Strategies in the Tianshan Mountain Northern Slope Economic Belt [PDF]

, 2017
Rongjin Yang, Wei Meng, Ning Duan, Shu Jian-min, Huiyuan Zhang, Jiaerheng Ahati, Hao Wang, Linbo Zhang, Qi Qiao, Weilun Yin, Qiang Zhang, Sun Meiying, H Fu, Z K Song, X H Chen, W Meng, J M Shu, L B Zhang, G Shen, S D Li, B Wu   +20 more
openalex   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Examining the unsustainable relationship between SDG performance, ecological footprint and international spillovers

Scientific Reports
For almost a decade, countries have been working to achieve the Sustainable Development Goals (SDGs). Yet progress on the SDGs across countries, as well as across the 17 goals, has proven frustratingly slow.
Mustafa Moinuddin, Simon Høiberg Olsen
doaj   +1 more source

WHO global strategy to eliminate cervical cancer as a public health problem: An opportunity to make it a disease of the past

, 2020
Princess Nothemba Simelela
openalex   +1 more source

OP04.08: Prenatal screening for Down syndrome: predictive value according to the different strategies implemented [PDF]

, 2010
C. Comas, M. Echevarría, M. Rodríguez, Ignacio Rodríguez, Bernat Serra   +4 more
openalex   +1 more source