Results 111 to 120 of about 169,569,647 (261)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Occupying Power: Strategies for Change in Occupy London
, 2015 Occupy London came to life on October 15th, 2011, part of a global day of occupations, and represents one of the longest standing protest camps from the Occupy movement.
Thorpe, S., Halvorsen, S.
core +3 more sources
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
New MeditThe relationship between wine products and the concepts of quality, identity, place, typicality and terroir is rooted in a deep socio-cultural and agricultural connection.
Giacomo Inserra +2 more
doaj +1 more source
PositivMasc: masculinities and violence against women among young people. Identifying discourses and developing strategies for change, a mixed-method study protocol. [PDF]
BMJ Open, 2020 Salazar M +4 more
europepmc +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Stress and Coherence as an Opportunity for Change
Studia Paedagogica IgnatianaStress resulting from trauma is typically viewed as having negative consequences. However, this article argues that such outcomes are not exclusively negative.
Anna Seredyńska
doaj +1 more source
BIENESTAR PSICOLÓGICO: EL ESTRÉS Y LA CALIDAD DE VIDA EN EL CONTEXTO LABORAL [PDF]
Revista Nacional de Administración, 2010 The changing environment in which we currentlylive has been translated into increased competitionand demands for organizations. This situationaffects employees by generating high levelsof pressure, which in turn become an everydaypart of work. This leads
María Martha Durán
doaj