Landscape of BRAF transcript variants in human cancer
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda+5 more
wiley +1 more source
Inversion of Biological Strategies in Engineering Technology: A Case Study of the Underwater Soft Robot. [PDF]
Chen S, Xu H, Zhang X, Jiang T, Ma Z.
europepmc +1 more source
Strategies of Adaptive Mobility in the Colombian‐Ecuadorian Littoral1
Norman E. Whitten
openalex +1 more source
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren+16 more
wiley +1 more source
Core and modifiable components of academic detailing: demonstration of implementation strategy development, tailoring, and documentation process. [PDF]
Domlyn AM+6 more
europepmc +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo+18 more
wiley +1 more source
Synergistic and Additive Effects of Multiple Threats Erode Phylogenetic and Life History Strategy Diversity in Testudines and Crocodilia. [PDF]
Rodríguez-Caro RC+10 more
europepmc +1 more source
A note on continuous games, the notion of strategy and Zermelo's axiom. [PDF]
Celso de Renna e Souza
openalex +1 more source