Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Psychological team diversity and strategy implementation [PDF]
The overwhelming majority of team or group composition studies are restricted to analyzing the link between team demographics and the content of specific strategic choices.
Boone,Christophe, Olffen, van,Woody
core +1 more source
From Global Strategy to Strategic Compass: Where Is the EU Heading? Egmont Security Policy Brief No, 121 December 2019 [PDF]
, 2019 Does the EU need a “Strategic Compass” to guide the implementation of the security and defence dimension of the European Union Global Strategy (EUGS)? Does it need a military strategy perhaps? And what about a review of the EUGS itself?
Biscop, Sven
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Gender and Development: An Evaluation of World Bank Support, 2002-08 [PDF]
, 2010 This evaluation reviews the World Bank's progress in gender integration from 2002 through 2008. Implementation of a 2001 gender strategy was initially strong, with integration into relevant projects peaking at 64% in 2003; but it declined between 2006 ...
core
Homodyne-like detection for state-discrimination in the presence of phase noise [PDF]
, 2016 We propose an innovative strategy to discriminate between two coherent states affected by either uniform or gaussian phase noise. The strategy is based on a homodyne-like detection scheme with photon-number-resolving detectors in the regime of low ...
Allevi, Alessia +3 more
core +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
An investigation into current production challenges facing the Libyan cement industry and the need for innovative Total Productive Maintenance (TPM) strategy [PDF]
, 2011 Purpose - The purpose of this paper is to investigate maintenance and production problems in the cement industry in Libya with particular emphasis on future implementation of Total Productive Maintenance (TPM).
Al-Habaibeh, A, Graisa, M
core +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source