Results 111 to 120 of about 1,979,826 (350)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

DIAGNÓSTICO E ANÁLISE DO MAPA ESTRATÉGICO DE UMA CORPORAÇÃO RELIGIOSA COM OBJETIVOS EDUCACIONAIS: ESTUDO DE CASO

open access: yesRevista Gestão Universitária na América Latina, 2011
International educational corporations have expanded their operations in the national arena, pressuring national organizations to improve their performance strategies and structure.
Jorge Gaio, Luiz Carlos Duclós
doaj  

A new approach to analyze strategy map using an integrated BSC and FUZZY DEMATEL [PDF]

open access: yesManagement Science Letters, 2012
Today, with ever-increasing competition in global economic conditions, the necessity of effective implementation of strategy map has become an inevitable and necessary.
Seyed Abdollah Heydariyeh   +2 more
doaj  

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

FORMATION OF THE SYSTEM OF BALANCED INDICES TO THE ASSESSMENT OF THE REGIONAL INVESTMENT STRATEGIES IMPLEMENTATION

open access: yesВестник Кемеровского государственного университета, 2014
The paper defines the possibility of using the balanced scorecard (BSC) to assess progress in the implementation of the region’s investment strategies. The necessity of application the main elements of the BSC – prospects, strategic map – for this task ...
E. A. Fedulova, N. S. Oshchepkova
doaj  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Efficient Decoding Algorithms for the Compute-and-Forward Strategy

open access: yes, 2014
We address in this paper decoding aspects of the Compute-and-Forward (CF) physical-layer network coding strategy. It is known that the original decoder for the CF is asymptotically optimal.
Mejri, Asma, Othman, Ghaya Rekaya-Ben
core  

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

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