Results 141 to 150 of about 8,149,283 (401)

The application of performance measures in the UK retail sector: an exploratory analysis [PDF]

, 2007
: An empirical investigation of the use of performance measurement by small and medium sized online retailers in the UK. The purpose of the study is to investigate type and range of performance measures applied and extent to which measures are likely ...
Ellis-Chadwick, Fiona, Gunawan, George, King, Malcolm   +2 more
core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Research on an Ecological Sensitivity Evaluation of Mountain-Type National Parks Under Multi-Modal Optimization: A Case Study of Shennongjia, China

Land
As ecologically sensitive zones within natural ecosystems, national parks demand more precise evaluation models for ecological sensitivity assessment. This study takes Shennongjia Forestry District, a pioneer among China’s first-batch national parks, as ...
Xingyu Zhou, Huan Huang, Shi Dai, Duanya Zheng, Jie Zhao   +4 more
doaj   +1 more source

Strategy for Development of Site-Specific Ubiquitin Antibodies. [PDF]

Front Chem, 2020
van Kruijsbergen I, Mulder MPC, Uckelmann M, van Welsem T, de Widt J, Spanjaard A, Jacobs H, El Oualid F, Ovaa H, van Leeuwen F.   +9 more
europepmc   +1 more source

Orchestration of the Marketing Strategy under Competitive Dynamics [PDF]

Constructing suitable marketing strategy and implementing it effectively is an art and science both like orchestration of a symphony. The discussion in this paper blends this analogy with the science of marketing demonstrating the levels of strategy ...
Rajagopal
core  

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Patterns of strategy development

, 1996
This paper builds on a multidimensional framework of strategy development to more clearly understand the processes by which strategy develops within organisations. It reports on a survey based research project which employs senior executives’ perceptions of the strategy development process in their organisations to examine how context specific ...
Bailey, Andy, Johnson, Gerry
openaire   +1 more source

Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza

Cell, 2020
Timothy R. Abbott, Girija R. Dhamdhere, Yanxia Liu, Xueqiu Lin, Laine Goudy, Leiping Zeng, Augustine Chemparathy, Stephen A. Chmura, Nicholas S. Heaton, R. Debs, Tara Pande, Drew Endy, Marie La Russa, D. Lewis, Lei S. Qi   +14 more
semanticscholar   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

A New Strategy for the Development of Highly Potent and Selective Plasmin Inhibitors

, 2012
Sebastian M. Saupe, Torsten Steinmetzer
openalex   +1 more source