Results 201 to 210 of about 8,149,283 (401)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Metallochaperone UreG serves as a new target for design of urease inhibitor: A novel strategy for development of antimicrobials. [PDF]

PLoS Biol, 2018
Yang X, Koohi-Moghadam M, Wang R, Chang YY, Woo PCY, Wang J, Li H, Sun H.   +7 more
europepmc   +1 more source

Development Strategies for Tourism Destinations: Tourism Sophistication vs. Resource Investments [PDF]

This paper investigates the effectiveness of development strategies for tourism destinations. We show that resource investments unambiguously increase tourism revenues and that increasing the degree of tourism sophistication, that is increasing the ...
Guido Candela, Rainer Andergassen
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Multi-strategy enterprise development optimizer for numerical optimization and constrained problems. [PDF]

Sci Rep
Cai X, Wang W, Wang Y.
europepmc   +1 more source

Design of experiments-based high-throughput strategy for development and optimization of efficient cell disruption protocols. [PDF]

Eng Life Sci, 2017
Glauche F, Pilarek M, Bournazou MNC, Grunzel P, Neubauer P.   +4 more
europepmc   +1 more source

Unraveling Community Dynamics: Management Strategies for SME Development

, 2023
Suarlin Suarlin
openalex   +2 more sources

AMERICA'S FORGOTTEN PEOPLE AND PLACES: ENDING THE LEGACY OF POVERTY IN THE RURAL SOUTH: DISCUSSION [PDF]

These comments discuss the presentations by Christy, Wenner, and Dassie ("A Microenterprise-Centered Economic Development Strategy for the Rural South: Sustaining Growth with Economic Opportunity") and Freshwater ("What Can Social Scientists Contribute ...
Baharanyi, Ntam, Boateng, Evelyn, Zabawa, Robert   +2 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A global chromoblastomycosis strategy and development of the global chromoblastomycosis working group. [PDF]

PLoS Negl Trop Dis
Smith DJ, Queiroz-Telles F, Rabenja FR, Hay R, Bonifaz A, Grijsen ML, Blaizot R, Messina F, Song Y, Lockhart SR, Jordan A, Cavanaugh AM, Litvintseva AP, Chiller T, Schito M, de Hoog S, Vicente VA, Cornet M, Dagne DA, Ramarozatovo LS, de Azevedo CMPES, Santos DWCL.   +21 more
europepmc   +1 more source