Results 311 to 320 of about 8,149,283 (401)

Refocusing on the foundations: strategy for child and adolescent health in Europe and Central Asia 2026-2030 - A healthy start for a healthy life. [PDF]

J Glob Health
Jullien S, Borisova I, Breda J, Carai S, Fontana G, Jovic A, Weber MM, Bivol O, Azzopardi Muscat N.   +8 more
europepmc   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Design and Usability of a Digitalized Compensatory Goal Management Training for Individuals with Brain Injury: A User-Centered Approach. [PDF]

Int J Telerehabil
Verhoog EM, Kessels RPC, Fasotti L, Bertens D.   +3 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Understanding the development and implementation of national quality of care and patient safety strategic documents: a scoping review. [PDF]

BMC Health Serv Res
Fernandes MM, Guerra-Paiva S, Soares AR, Spiteri R, Triantafyllou C, Vasileiou K, Stridborg M, Fonseca V, Breda J, Sousa P.   +9 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

From policy to practice: why the WHO's Africa rehabilitation strategy 2025-2035 risks failure without educational reform. [PDF]

Front Med (Lausanne)
Npochinto Moumeni I.
europepmc   +1 more source

Response to Letter Regarding "Herbal Medicine Combined With Chemotherapy in Advanced NSCLC". [PDF]

Integr Cancer Ther
Kim DH, Lee KJ, Park SJ.
europepmc   +1 more source

DEVELOPMENT OF A NEW MARKETING STRATEGY FOR ALROSA [PDF]

, 2016
Kochnova, M., Kovaleva, E.
core  

Integrating human-AI collaboration into translation education: A comprehensive protocol for assessment, diagnosis, and strategy development. [PDF]

PLoS One
Ren X, Wang R.
europepmc   +1 more source