Results 111 to 120 of about 1,522,732 (367)

Risk Stratification in Differentiated Thyroid Cancer: From Detection to Final Follow-up.

open access: yesJournal of Clinical Endocrinology and Metabolism, 2019
CONTEXT Modern management of differentiated thyroid cancer requires individualized care plans which tailor the intensity of therapy and follow-up to the estimated risks of recurrence and disease-specific mortality.
R. M. Tuttle, A. S. Alzahrani
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Redox stratification of an ancient lake in Gale crater, Mars

open access: yesScience, 2017
The depths of an ancient lake on Mars Gale crater on Mars was once a lake fed by rivers and groundwater. Hurowitz et al. analyzed 3.5 years of data from the Curiosity rover’s exploration of Gale crater to determine the chemical conditions in the ancient ...
J. Hurowitz   +25 more
semanticscholar   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Classroom Interaction and Pedagogic Practice: A Bernsteinian Analysis

open access: yesInternational Journal of Sociology of Education, 2013
Language development through social interaction is a key element in early childhood pedagogy. Because children enter prekindergarten programs at an age in which language and social competencies are still developing, teachers of young children have a ...
Stephanie C. Smith
doaj   +1 more source

Publication stratification [PDF]

open access: yesJournal of Thrombosis and Haemostasis, 2014
F R, Rosendaal, P H, Reitsma
openaire   +2 more sources

Self-consistent theory of turbulent transport in the solar tachocline. III. Gravity waves

open access: yes, 2007
To understand the fundamental physical processes important for the evolution of solar rotation and distribution of chemical species, we provide theoretical predictions for particle mixing and momentum transport in the stably stratified tachocline.
Brummell   +38 more
core   +1 more source

Prediction and Risk Stratification of Kidney Outcomes in IgA Nephropathy.

open access: yesAmerican Journal of Kidney Diseases, 2019
RATIONALE & OBJECTIVE Immunoglobulin A nephropathy (IgAN) is common worldwide and has heterogeneous phenotypes. Predicting long-term outcomes and stratifying risk are important for clinical decision making and designing future clinical trials.
Tingyu Chen   +9 more
semanticscholar   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

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