Results 131 to 140 of about 1,522,732 (367)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Erratum: Christodouleas JP, Baumann BC, He J, Hwang W‐T, Tucker KN, Bekelman JE, Tangen CM, Lerner SP, Guzzo TJ and Malkowicz SB. Optimizing bladder cancer locoregional failure risk stratification after radical cystectomy using SWOG 8710 Cancer. 2014;120:1272‐80 [PDF]

, 2014

openalex   +1 more source

Validation of risk stratification schemes for predicting stroke and thromboembolism in patients with atrial fibrillation: nationwide cohort study

British medical journal, 2011
Objectives To evaluate the individual risk factors composing the CHADS2 (Congestive heart failure, Hypertension, Age≥75 years, Diabetes, previous Stroke) score and the CHA2DS2-VASc (CHA2DS2-Vascular disease, Age 65-74 years, Sex category) score and to ...
J. Olesen, G. Lip, M. L. Hansen, P. Hansen, J. Tolstrup, J. Lindhardsen, C. Selmer, Ole Ahlehoff, A. Olsen, G. Gislason, C. Torp-Pedersen   +10 more
semanticscholar   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Experimental Analysis of the Stratification Characteristics of a Water Storage Tank with New Stratifier

Zhileng xuebao, 2016
Test rig is established to measure the stratification characteristics of a water storage tank with new stratifier. When the initial temperature of the tank is 50℃ and the inlet temperature of the water is 20 ℃, the temperature of each layer in the tank ...
Wang Chongyuan, Zhang Hua, Wang Zilong
doaj  

Validation of Stratification-Driven Phytoplankton Biomass and Nutrient Concentrations in the Northeast Atlantic Ocean as Simulated by EC-Earth

Geosciences, 2019
We validated simulations of the Earth system model (ESM) EC-Earth-NEMO of present-day temperature, salinity, nutrient, and chlorophyll a profiles with in situ observations in the Northeast Atlantic Ocean (29−63º N).
Nomikos Skyllas, Richard Bintanja, Anita G. J. Buma, Corina P. D. Brussaard, Matthias Gröger, Jenny Hieronymus, Willem H. van de Poll   +6 more
doaj   +1 more source

Effect of Scarification and Stratification treatments on Germination and Seedling Vigour of Teak (Tectona grandis Linn.f) Drupes [PDF]

, 2023
S. Venkatesan, Poomaruthai Masilamani, T. Eevera, P. Janaki, S Sundareswaran, P. Rajkumar, Rajkumar P   +6 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Heterogeneidade espacial e temporal da qualidade da água no reservatório Rio das Pedras (Complexo Billings, São Paulo)

Revista Ambiente & Água, 2009
The objective of the present study was to evaluate spatial and temporal patterns of limnological characteristics of the Rio das Pedras Reservoir (Billings Complex, São Bernardo do Campo, São Paulo – Brazil).
Viviane Moschini-Carlos, Paula Regina Padial, Marcelo Pompêo   +2 more
doaj