Results 141 to 150 of about 30,949 (234)

Whose city is it? Mapping perceived urban livability with citizen-guided AI. [PDF]

NPJ Urban Sustain
Campomanes V F, Abascal A, Oliveira LT, Kuffer M, Dijkstra AM, Stein A, Belgiu M.   +6 more
europepmc   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

Integrative multiomic profiling of cfDNA methylation and EV-miRNAs identifies immunotherapy-outcome molecular subtypes in NSCLC. [PDF]

J Immunother Cancer
Onieva JL, Pérez-Ruiz E, Figueroa-Ortiz LC, Jurado JM, Martínez B, Carlos Benítez J, Rueda-Domínguez A, Barragán I.   +7 more
europepmc   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

A non-local diffusion magnetic resonance imaging tract density biomarker to stratify, predict, and interpret survival rates in human glioblastoma. [PDF]

Neuro Oncol
Falcó-Roget J, Basile GA, Janus A, Lillo S, Politi LS, Argasinski JK, Cacciola A.   +6 more
europepmc   +1 more source

Bioprinted Tumor Microenvironment Models Reveal Immune Evasion and Guide CAR‐NK Therapeutic Strategies

Advanced Science, EarlyView.
This study presents a 3D embedded bioprinting platform that recapitulates key stromal features of the tumor microenvironment using fibroblasts and lung‐derived ECM. The model enables functional assessment of CAR‐NK cells and provides a versatile tool to support the development of next‐generation immunotherapeutic strategies against solid tumors ...
Dahong Kim, Seona Jo, In‐Hwan Jang, Yu‐Jin Kim, Youngmee Jung, Junhyoung Ahn, Hyungjun Lim, Jae Jong Lee, Kangwon Lee, Tae‐Don Kim, Su A Park   +10 more
wiley   +1 more source

Multimodal prediction of metastatic relapse using federated deep learning in soft-tissue sarcoma with a complex genomic profile. [PDF]

Sci Rep
Maussion C, Coindre JM, Blay JY, Schutte K, Camara A, Loarer FL, Perret R, Jean-Denis M, Meurgey A, Ducimetiere F, Giraud A, Courrèges JB, Meeus P, Michot A, Bendjebbar E, Ogier du Terrail J, Italiano A, Karanian M.   +17 more
europepmc   +1 more source

Predictive value of baseline C-reactive protein for periprocedural myocardial infraction of higher risk stratifications: A retrospective cohort clinical study. [PDF]

Anatol J Cardiol, 2018
Yao M, Zhao L, Wu L, Zhang W, Luan Y, Song J, Fu G, Zhu J.   +7 more
europepmc   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Plasma proteomics improves risk prediction in heart failure and reveals unique biology in chronic chagas cardiomyopathy. [PDF]

PLoS Negl Trop Dis
Patané JSL, Giugni FR, Rosa RS, Marcondes-Braga FG, Mansur AJ, Pereira AC, Krieger JE.   +6 more
europepmc   +1 more source