Results 91 to 100 of about 3,135 (215)
Advanced Science, EarlyView.TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin +11 more
wiley +1 more source
Advanced Science, EarlyView.A quasi‐periodic Dart‐Kite (QDK) metastructure with a golden‐ratio‐constrained strong–weak bond network simultaneously enhances strength, toughness, and damage tolerance. Its distributed topology enables predictable, tailorable crack paths for precise fracture control and stable mechanics, demonstrating a high‐performance, controllable architecture ...
Tianyu Gao +3 more
wiley +1 more source
, 2000 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This dissertation focuses on the mathematical design of a unified shape kernel for geometric computing, with possible applications to computer aided design (
Gomes, Abel Joao Padrao
core
Advanced Science, EarlyView.Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole +17 more
wiley +1 more source
Lattice-valued uniform convergence spaces the case of enriched lattices
, 2008 Using a pseudo-bisymmetric enriched cl-premonoid as the underlying lattice, we examine different categories of lattice-valued spaces. Lattice-valued topological spaces, uniform spaces and limit spaces are described, and we produce a new definition of ...
Craig, Andrew Philip Knott
core
Advanced Science, EarlyView.Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu +15 more
wiley +1 more source
Triple‐Mode Ferroelectric Thin‐Film Transistor for Hybrid Electrical–Optical Reservoir Computing
Advanced Science, EarlyView.A triple‐mode ferroelectric thin‐film transistor is developed by integrating Si3N4/HZO/IGZO layers to realize three independent memory modes: electric long‐term, electric short‐term, and optical short‐term. This single‐device architecture functions as both a reservoir and readout layer, achieving 92.43% MNIST accuracy. It offers a fully hardware‐based,
Hyeonho Lee +9 more
wiley +1 more source
Advanced Science, EarlyView.This study establishes an interpretable machine learning framework that disentangles the intrinsic molecular efficacy of passivators from experimental platform effects—enabling unbiased, high‐throughput discovery of effective perovskite surface modifiers.
Jing Zhang +5 more
wiley +1 more source
Stratified manifolds with corners
We define categories of stratified manifolds (s-manifolds) and stratified manifolds with corners (s-manifolds with corners). An s-manifold X of dimension n is a Hausdorff, locally compact topological space X with a stratification X = ∐i∈I Xi into locally
Joyce, Dominic
core +1 more source
Advanced Science, EarlyView.Two distinct slip‐link mechanisms – the slide‐ring pulley effect and highly entangled chains – are combined in a water‐rich double network hydrogel, achieving synergistic toughening, near‐complete reversibility, and exceptional friction tear resistance at >$>$91 wt.% water.
Subhankar Mandal +5 more
wiley +1 more source