AB1042 PATIENT CHARACTERISTICS AND SPA FEATURES IN RECENTLY DIAGNOSED AXIAL SPONDYLOARTHRITIS PATIENTS STRATIFIED FOR CLINICAL DIAGNOSIS AND ASAS CLASSIFICATION CRITERIA; RESULTS FROM STANDARD-OF-CARE COHORT [PDF]
, 2023 J. M. Nijmeijer +4 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Children and Young People's Priorities for Mental Health Research in Northern Ireland
Health ExpectationsIntroduction There are a number of factors contributing to the poor mental health of children and young people (CYP) specific to life in Northern Ireland (NI).
Siobhan O'Neill +6 more
doaj +1 more source
Patterns of self-reported care in a cohort of prostate cancer survivors: Implications for risk-stratified care. [PDF]
J Geriatr Oncol, 2020 Nekhlyudov L +3 more
europepmc +1 more source
Prostate CAncer Integrated Risk Evaluation (P-CARE): A Model to Stratify Risk of Any, Metastatic, and Fatal Prostate [PDF]
Anna Dornisch +14 more
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Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
P-210 YI Demographic and Clinical Differences Related to Pediatric IBD Care Among Hospitals Stratified by Annual Case Volume [PDF]
, 2016 Chaitanya Pant +2 more
openalex +1 more source
Implication of using cognitive function-related simple questions to stratify the risk of long-term care need: population-based prospective study in Kobe, Japan [PDF]
, 2022 Shinsuke Kojima +9 more
openalex +1 more source